{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:30:26Z","timestamp":1791066626773,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The most characteristic symptom of Alzheimer's disease (AD) is episodic memory impairment, which is closely associated with atrophy of the entorhinal cortex. Meanwhile, atypical symptoms are more frequent in early\u2010onset AD than in late\u2010onset AD, suggesting that the former subtype has less atrophy in the entorhinal cortex. Therefore, we investigated whether the degree of atrophy in the entorhinal cortex is different between the two subtypes of AD using the voxel\u2010based specific regional analysis system for AD (VSRAD) targeting this region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of 198 patients with AD. They were divided into two groups, that is, the early\u2010onset AD group with the onset under age 65\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u200918) and the late\u2010onset AD group with the onset at age 65\u2009years or over (<jats:italic>n<\/jats:italic>\u2009=\u2009180). The degree of atrophy in the entorhinal cortex was quantified by application of the VSRAD to magnetic resonance imaging data, and a <jats:italic>Z<\/jats:italic>\u2010score &gt;2 was defined as significant atrophy according to previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The early\u2010onset group had significantly lower <jats:italic>Z<\/jats:italic>\u2010scores than the late\u2010onset group (mean\u2009\u00b1\u2009SD: 1.83\u2009\u00b1\u20090.92 vs 2.90\u2009\u00b1\u20091.40, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The analysis of covariance with possible confounding factors as covariates also showed that <jats:italic>Z<\/jats:italic>\u2010scores were significantly lower in the early\u2010onset group than in the late\u2010onset group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The proportion of patients with atrophy was significantly lower in the early\u2010onset group than in the late\u2010onset group (44% vs 71%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study using the VSRAD suggests that early\u2010onset AD shows less atrophy in the entorhinal cortex than late\u2010onset AD. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.3834","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T08:43:16Z","timestamp":1338194596000},"page":"372-376","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of entorhinal cortex atrophy between early\u2010onset and late\u2010onset Alzheimer's disease using the VSRAD, a specific and sensitive voxel\u2010based morphometry"],"prefix":"10.1002","volume":"28","author":[{"given":"Yuzuru","family":"Shibuya","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Kawakatsu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yamagata University School of Medicine  Yamagata 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