{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T19:22:12Z","timestamp":1772392932637,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Musculoskeletal disorders are common and often lead to chronic pain in older adults. Because the efficacy of interventions varies with the duration of pain, the identification of early biomarkers for chronic pain would have important public health consequences. Imaging of functional connectivity differences between brain regions might identify some of the earliest functional consequences of a disease process. We tested the hypothesis that chronic musculoskeletal pain in older persons is associated with changes in functional brain connectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We used resting\u2010state functional magnetic resonance imaging and a spherical seed\u2010based region of interest approach to assess functional connectivity of brain regions on a sample of 128 (64 who reported chronic musculoskeletal pain and 64 demographically matched, pain free) nondemented older adults from the Memory and Aging Project, a clinical\u2010pathological cohort study of aging and dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older adults with chronic pain showed greater functional connectivity between the posterior cingulate and left insula, left superior temporal gyrus, and left cerebellum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic musculoskeletal pain is associated with a specific pattern of functional connectivity between brain regions among older adults. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.3898","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T06:01:07Z","timestamp":1352095267000},"page":"858-867","source":"Crossref","is-referenced-by-count":22,"title":["Functional connectivity networks associated with chronic musculoskeletal pain in old age"],"prefix":"10.1002","volume":"28","author":[{"given":"S.","family":"Duke Han","sequence":"first","affiliation":[{"name":"Department of Behavioral Sciences Rush University Medical Center  Chicago IL USA"},{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago IL USA"},{"name":"Mental Health Care Group VA Long Beach Healthcare System  Long Beach CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center  Chicago IL 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