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The present work measured and analyzed immune molecules involved in the innate immunity on cluster of differentiation 14 (CD14+) monocytes trying to investigate any relationship among late\u2010onset depression (LOD) and Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immune molecules were evaluated in monocytes of AD, LOD patients, and controls using flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interestingly, interleukin 1 beta (IL\u20101\u03b2) expressing CD14+ monocytes were increased in AD patients compared with controls. LOD presented intermediate frequency of CD14+ monocytes expressing IL\u20101\u03b2 between controls and AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results suggest that an increased frequency of CD14+ monocytes expressing IL\u20101\u03b2 level could be a stage marker related to the pathophysiology of dementia process between normal aging and AD. 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