{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:14Z","timestamp":1790377094853,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cognitive dysfunction is prevalent in older adults with bipolar disorder (BD). High white matter hyperintensity (WMH) burden, a marker of white matter disease, detected on T2\/fluid\u2010attenuated inversion recovery brain magnetic resonance imaging (MRI) has been consistently reported in BD across all age ranges, including older adults. Yet, whether high WMH burden is related to the excess cognitive impairment present in older adults with BD is unknown. Therefore, we examine whether higher WMH burden is related to worse cognitive function in older adults with BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional study of 27 non\u2010demented BD patients aged \u226550\u2009years and 12 similarly aged mentally healthy comparators (controls). Subjects underwent both brain MRI and comprehensive neurocognitive assessment. We employed correlational analyses to evaluate the burden of WMH and the relationship between WMH and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although BD subjects had worse performance in all cognitive domains, BD subjects had less total WMH burden (\n                      <jats:italic>t<\/jats:italic>\n                      [13.4]\u2009=\u2009\u22123.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). In control subjects, higher WMH was related to lower global cognitive function (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u2009\u22120.57,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). However, WMH did not correlate with neuropsychological performance in BD subjects. Further, BD and control subjects did not differ with respect to total gray and hippocampal volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive dysfunction in late\u2010life BD does not appear to be due primarily to processes related to increased WMH or reduced gray matter volume. Future longitudinal studies should examine other potential neuroprogressive pathways such as inflammation, mitochondrial dysfunction, serum anticholinergic burden, and altered neurogenesis. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.4021","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T02:36:35Z","timestamp":1378348595000},"page":"421-427","source":"Crossref","is-referenced-by-count":28,"title":["Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age"],"prefix":"10.1002","volume":"29","author":[{"given":"Soham","family":"Rej","sequence":"first","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl A.","family":"Butters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry 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