{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:54:05Z","timestamp":1784775245936,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Prior studies of US Hispanics, largely performed on the East Coast, have found a younger age of dementia onset than in White non\u2010Hispanics. We performed a cross\u2010sectional study to examine clinical and sociodemographic variables associated with age of dementia diagnosis in older Hispanics and White, non\u2010Hispanics in southern California.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred ninety (110 Hispanic and 180 White non\u2010Hispanic) community dwelling, cognitively symptomatic subjects, aged 50\u2009years and older, were assessed and diagnosed with probable Alzheimer's disease or probable vascular dementia. Apolipoprotein E (APOE) genotype was assessed in a subset of cases. Analysis of variance and multiple stepwise linear regression were used to assess main effects and interactions of ethnicity with dementia severity (indexed by mini mental state examination scores) and other sociodemographic and clinical variables on age of dementia diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hispanics were younger by an average of 4\u2009years at the time of diagnosis, regardless of dementia subtype, despite a similar prevalence of the APOE \u03b54 genotype. The earlier age at diagnosis for Hispanics was not explained by gender, dementia severity, years of education, history of hypercholesterolemia, hypertension, or diabetes. Only ethnicity was significantly associated with age of onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings confirm that US Hispanics living in the southwestern USA tend to be younger at the time of dementia diagnosis than their White non\u2010Hispanic counterparts. As this is not explained by the presence of the APOE \u03b54 genotype, further studies should explore other cultural, medical, or genetic risk factors influencing the age of dementia onset in this population. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4040","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T05:11:07Z","timestamp":1391058667000},"page":"586-593","source":"Crossref","is-referenced-by-count":52,"title":["Younger age of dementia diagnosis in a Hispanic population in southern California"],"prefix":"10.1002","volume":"29","author":[{"given":"L. 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