{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:48:47Z","timestamp":1789966127994,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Little evidence is available about how quality of life (QoL) changes as dementia progresses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We explored QoL trajectories over a 20\u2010month period and examined what predicted change in QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dementia (PwD)) participating in the Memory Impairment and Dementia Awareness Study rated their QoL using the QoL\u2010Alzheimer's Disease Scale at baseline and at 20\u2010month follow\u2010up. PwD also rated their mood and quality of relationship with the carer. In each case, the carer rated his or her level of stress and perceived quality of relationship with the PwD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no change in mean QoL score. Nearly one\u2010third of PwD rated QoL more positively at 20\u2010month follow\u2010up and nearly one\u2010third rated QoL more negatively. These changes could be regarded as reliable in one\u2010quarter of the sample. Participants taking acetylcholinesterase\u2010inhibiting medication at baseline were more likely to show a decline in QoL score. There were no other significant differences between those whose scores increased, decreased or stayed the same on any demographic or disease\u2010related variables, or in mood or perceived quality of relationship with the carer. Whereas baseline QoL score was the strongest predictor of QoL at 20\u2009months, the quality of relationship with the carer as perceived by the PwD was also independently a significant predictor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a degree of individual variation in QoL trajectories. Use of acetylcholinesterase\u2010inhibiting medication appears linked to decline in QoL score, whereas positive relationships with carers play an important role in maintaining QoL in early\u2010stage dementia. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4044","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T12:07:54Z","timestamp":1382443674000},"page":"616-623","source":"Crossref","is-referenced-by-count":43,"title":["Trajectories of quality of life in early\u2010stage dementia: individual variations and predictors of change"],"prefix":"10.1002","volume":"29","author":[{"given":"Linda","family":"Clare","sequence":"first","affiliation":[{"name":"Bangor University  Bangor UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Woods","sequence":"additional","affiliation":[{"name":"Bangor University  Bangor UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Nelis","sequence":"additional","affiliation":[{"name":"Bangor University  Bangor 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