{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T01:57:37Z","timestamp":1791683857473,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas' Charity","doi-asserted-by":"publisher","award":["PCDTMRA"],"award-info":[{"award-number":["PCDTMRA"]}],"id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PCDKMRA"],"award-info":[{"award-number":["PCDKMRA"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Dopamine D2\/3 receptor positron emission tomography tracers have guided antipsychotic prescribing in young people with schizophrenia by establishing a \u2018therapeutic window\u2019 of striatal D2\/3 receptor occupancy. Older people, particularly those with dementia, are highly susceptible to motor side effects and may benefit from the appropriate application of imaging techniques. The study aimed to adapt [<jats:sup>18<\/jats:sup>F]fallypride imaging for use in occupancy studies in Alzheimer's disease (AD) and to investigate whether data acquisition could be made more tolerable by piloting the protocol in a small sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six participants with AD (three men; 85.0\u2009\u00b1\u20095.6\u2009years old; MMSE\u2009=\u200916.0\u2009\u00b1\u20092.4) were recruited prior to commencing amisulpride for the treatment of psychosis and associated agitation. [<jats:sup>18<\/jats:sup>F]fallypride binding potential (<jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub>) was determined using an interrupted scanning protocol at baseline (<jats:italic>n<\/jats:italic>\u2009=\u20096) and after 27.0\u2009\u00b1\u20096.1\u2009days of amisulpride (25\u201350\u2009mg) treatment (<jats:italic>n<\/jats:italic>\u2009=\u20094). D2\/3 occupancy was calculated by percentage reduction in <jats:italic>BP<\/jats:italic><jats:sub>ND<\/jats:sub> between scanning sessions. Image data were re\u2010analysed after reducing individual sampling times to 20\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The protocol was tolerated well, apart from the final (40\u2009min) session of the post\u2010treatment scan in one participant. Higher occupancies were achieved in the striatum (caudate 47\u201370%, putamen 31\u201358%) and thalamus (54\u201376%) than in the inferior temporal gyrus (27\u201343%). There was high agreement between occupancy values derived using longer and shorter sampling times (mean absolute difference 6.1% in the inferior temporal gyrus; &lt;2% all other regions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The protocol is feasible for use in AD and represents the first step towards establishing dose\u2013occupancy relationships across older clinical populations. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4090","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T07:05:53Z","timestamp":1393571153000},"page":"1001-1009","source":"Crossref","is-referenced-by-count":14,"title":["Towards a therapeutic window of D2\/3 occupancy for treatment of psychosis in Alzheimer's disease, with [<sup>18<\/sup>F]fallypride positron emission tomography"],"prefix":"10.1002","volume":"29","author":[{"given":"Chloe","family":"Clark\u2010Papasavas","sequence":"first","affiliation":[{"name":"Department of Old Age Psychiatry Institute of Psychiatry, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel T.","family":"Dunn","sequence":"additional","affiliation":[{"name":"St Thomas' PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering King's College London  London 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