{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:45:03Z","timestamp":1791049503541,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T00:00:00Z","timestamp":1396051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24791373"],"award-info":[{"award-number":["24791373"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to clarify the concordance of diagnostic abilities and interobserver agreement between <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) positron emission tomography (PET) and brain perfusion single photon\u2010emission computed tomography (SPECT) in patients with Alzheimer's disease (AD) who were diagnosed according to the research criteria of the National Institute of Aging\u2010Alzheimer's Association Workshop.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five patients with \u201cAD and mild cognitive impairment (MCI)\u201d (<jats:italic>n<\/jats:italic>\u2009=\u200940) and \u201cnon\u2010AD\u201d (<jats:italic>n<\/jats:italic>\u2009=\u200915) were evaluated with <jats:sup>18<\/jats:sup>F\u2010FDG PET and <jats:sup>99m<\/jats:sup>Tc\u2010ethyl cysteinate dimer (ECD) SPECT during an 8\u2010week period. Three radiologists independently graded the regional uptake in the frontal, temporal, parietal, and occipital lobes as well as the precuneus\/posterior cingulate cortex in both images. Kappa values were used to determine the interobserver reliability regarding regional uptake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The regions with better interobserver reliability between <jats:sup>18<\/jats:sup>F\u2010FDG PET and <jats:sup>99m<\/jats:sup>Tc\u2010ECD SPECT were the frontal, parietal, and temporal lobes. The <jats:sup>99m<\/jats:sup>Tc\u2010ECD SPECT agreement in the occipital lobes was not significant. The frontal, temporal, and parietal lobes showed good correlations between <jats:sup>18<\/jats:sup>F\u2010FDG PET and <jats:sup>99m<\/jats:sup>Tc\u2010ECD SPECT in the degree of uptake, but the occipital lobe and precuneus\/posterior cingulate cortex did not show good correlations. The diagnostic accuracy rates of \u201cAD and MCI\u201d ranged from 60% to 70% in both of the techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The degree of uptake on <jats:sup>18<\/jats:sup>F\u2010FDG PET and <jats:sup>99m<\/jats:sup>Tc\u2010ECD SPECT showed significant correlations in the frontal, temporal, and parietal lobes. The diagnostic abilities of <jats:sup>18<\/jats:sup>F\u2010FDG PET and <jats:sup>99m<\/jats:sup>Tc\u2010ECD SPECT for \u201cAD and MCI,\u201d when diagnosed according to the National Institute of Aging\u2010Alzheimer's Association Workshop criteria, were nearly identical. 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