{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:31:25Z","timestamp":1785270685104,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30CA086862-09"],"award-info":[{"award-number":["5P30CA086862-09"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA122934"],"award-info":[{"award-number":["R01CA122934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The term \u201cchemobrain\u201d is sometimes used to denote deficits in neuropsychological functioning that may occur as a result of cancer treatment. As breast cancer survivors now commonly reach late life, it is not known whether previous exposure to chemotherapy may affect long\u2010term risk for cognitive impairment. To help address this concern, this study tested whether successfully surviving chemotherapy earlier in life was associated with later differences in brain metabolic function as an older adult compared to controls. This question was examined using positron emission tomography measures of brain glucose metabolism in elderly women cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breast cancer survivors (<jats:italic>N<\/jats:italic>\u2009=\u200910), currently free of recurrent cancer and without a diagnosis of a cognitive disorder, were compared to matched healthy controls (<jats:italic>N<\/jats:italic>\u2009=\u200910). All subjects were imaged at rest with [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose. Images were analyzed semi\u2010quantitatively using the Alzheimer's Discrimination Tool and a volume of interest\u2010based approach derived from co\u2010registered magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose uptake (normalized to global) was significantly lower in the survivors compared with control subjects in bilateral orbital frontal regions, consistent with differences between the groups in cognition and executive function (i.e., Trail Making Test, Part B and mini\u2010mental state examination) and despite no significant differences with respect to age, education, intelligence, or working memory. None of the survivors and only one control manifested a global positron emission tomography score consistent with an Alzheimer's disease metabolic pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Breast cancer survivors treated with chemotherapy may manifest long\u2010term changes in brain glucose metabolism indicative of subtle frontal hypometabolism, a finding consistent with results from neuropsychological testing and other imaging modalities. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4189","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T10:04:29Z","timestamp":1409565869000},"page":"587-594","source":"Crossref","is-referenced-by-count":36,"title":["Frontal hypometabolism in elderly breast cancer survivors determined by [<sup>18<\/sup>F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1197-6714","authenticated-orcid":false,"given":"Laura L. Boles","family":"Ponto","sequence":"first","affiliation":[{"name":"Department of Radiology University of Iowa Carver College of Medicine  Iowa City IA USA"},{"name":"Positron Emission Tomography Imaging Center, Department of Radiology University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Menda","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Iowa Carver College of Medicine  Iowa City IA USA"},{"name":"Positron Emission Tomography Imaging Center, Department of Radiology University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Magnotta","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Iowa Carver College of Medicine  Iowa City IA USA"},{"name":"Department of Psychiatry University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torricia H.","family":"Yamada","sequence":"additional","affiliation":[{"name":"Veterans Administration Health Care System  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie L.","family":"Denburg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Carver College of Medicine  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2008.n.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2073"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617703970019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01725.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490510905"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21102"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1401.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.04.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3086"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-006-0066-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0114-2"},{"key":"e_1_2_8_14_1","first-page":"286","article-title":"L'examen psychologique dans les cas d'encephalopathie traumatique","volume":"28","author":"Rey A","year":"1941","journal-title":"Arch Psychol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/s130303169"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9380-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.04.015"},{"key":"e_1_2_8_18_1","volume-title":"A Compendium of Neuropsychological Tests","author":"Spreen O","year":"1998"},{"key":"e_1_2_8_19_1","volume-title":"Wechsler Adult Intelligence Scale\u2010III (WAIS\u2010III)","author":"Wechsler D","year":"1997"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.03.009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2010.22.1.48"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:17:26Z","timestamp":1696407446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/gps.4189"],"URL":"https:\/\/doi.org\/10.1002\/gps.4189","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}