{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:52:28Z","timestamp":1784325148519,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024989"],"award-info":[{"award-number":["UL1RR024989"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NV Organon\/Merck","award":["MISP 39358"],"award-info":[{"award-number":["MISP 39358"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In spite of growing numbers of older people, there are few treatment studies on late\u2010life bipolar disorder (BD). This was a 12\u2010week prospective, open\u2010label trial to assess efficacy and tolerability of adjunct asenapine in non\u2010demented older adults (\u226560\u2009years) with sub\u2010optimal previous response to BD treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asenapine was initiated at 5\u2009mg\/day and titrated as tolerated. Effects on global psychopathology were measured with Clinical Global Impression, bipolar version (CGI\u2010BP), and the Brief Psychiatric Rating Scale (BPRS). Mood polarity severity was measured with the Hamilton Depression Rating Scale, Montgomery Asberg Depression Rating Scale, and Young Mania Rating Scale. Other outcomes included the World Health Organization Disability Assessment Schedule II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen individuals were enrolled (mean age 68.6, <jats:italic>SD<\/jats:italic> 6.12; 53% female; 73% Caucasian, 13% African American, and 7% Asian). There were 4\/15 (27%) individuals who prematurely terminated the study, whereas 11\/15 (73%) completed the study. There were significant improvements from baseline on the BPRS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), on CGI\u2010BP overall (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and on CGI\u2010BP mania (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and depression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) subscales. The mean dose of asenapine was 11.2 (<jats:italic>SD<\/jats:italic> 6.2)\u2009mg\/day. The most common reported side effects were gastrointestinal discomfort (<jats:italic>n<\/jats:italic>\u2009=\u20095, 33%), restlessness (<jats:italic>n<\/jats:italic>\u2009=\u20092, 13%), tremors (<jats:italic>n<\/jats:italic>\u2009=\u20092, 13%), cognitive difficulties (<jats:italic>n<\/jats:italic>\u2009=\u20092, 13%), and sluggishness (<jats:italic>n<\/jats:italic>\u2009=\u20092, 13%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older people with BD had global improvements on asenapine. Most reported adverse effects were mild and transient, but adverse effects prompted drug discontinuation in just over one quarter of patients. Although risks versus benefits in older people must always be carefully considered, asenapine may be a treatment consideration for some non\u2010demented geriatric BD patients. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4213","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T10:13:26Z","timestamp":1414491206000},"page":"710-719","source":"Crossref","is-referenced-by-count":32,"title":["Asenapine in the treatment of older adults with bipolar disorder"],"prefix":"10.1002","volume":"30","author":[{"given":"Martha","family":"Sajatovic","sequence":"first","affiliation":[{"name":"Neurological and Behavioral Outcomes Center Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"},{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"},{"name":"Department of Neurology Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Dines","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna","family":"Fuentes\u2010Casiano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Athey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Sams","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Clegg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Locala","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Stagno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Tatsuoka","sequence":"additional","affiliation":[{"name":"Neurological and Behavioral Outcomes Center Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"},{"name":"Department of Neurology Case Western Reserve University School of Medicine and University Hospitals Case Medical Center  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318187135f"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.12.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.5.672"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200005000-00011"},{"key":"e_1_2_9_6_1","volume-title":"Hopkins Verbal Learning Test\u2014Revised (HVLT\u2010R)","author":"Brandt J","year":"2001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.05.027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"CalabreseJ StetL KotariH et al.2010.Asenapine as adjunctive treatment for bipolar mania: a placebo\u2010controlled 12\u2010week study and 40\u2010week extension. 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