{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:36:54Z","timestamp":1789990614205,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labor Sciences Research Grant for Research on Psychiatric and Neurological Diseases and Mental Health"},{"name":"industry to support private universities building up their foundations of strategic research","award":["S0801035"],"award-info":[{"award-number":["S0801035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta\u2010amyloid (A\u03b2) pathology on the pathology of GD by using [<jats:sup>18<\/jats:sup>F]florbetapir PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three elderly patients (76.7\u2009\u00b1\u20094.2\u2009years) and 22 healthy controls (HC; 72.0\u2009\u00b1\u20094.5\u2009years, average\u2009\u00b1\u2009SD) were examined by [<jats:sup>18<\/jats:sup>F]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini\u2010Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut\u2010off value of 1.08 for SUVR was defined as A\u03b2\u2010positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients and HC, 39.4% and 27.3%, respectively, were beta\u2010amyloid\u2010positive. The onset age of GD was significantly correlated with SUVR (<jats:italic>r<\/jats:italic>\u2009=\u20090.44, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared to patients without A\u03b2 (GD\u2010A\u03b2), patients with A\u03b2 (GD\u2009+\u2009A\u03b2) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD\u2009+\u2009A\u03b2 had significantly older average\u2009\u00b1\u2009SD age at onset of GD (73.6\u2009\u00b1\u20097.1 versus 58.7\u2009\u00b1\u200917.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and significantly shorter average\u2009\u00b1\u2009SD time between onset of GD and PET scan day (3.1\u2009\u00b1\u20095.2\u2009years versus 18.1\u2009\u00b1\u200918.6\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) than GD\u2010A\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results showed that the rate of A\u03b2 positivity was higher in late\u2010onset GD and that onset\u2010age was associated with SUVR, suggesting that the later the onset of GD, the more A\u03b2 pathology affected its onset. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4215","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T16:25:53Z","timestamp":1413908753000},"page":"720-728","source":"Crossref","is-referenced-by-count":27,"title":["Amyloid imaging with [<sup>18<\/sup>F]florbetapir in geriatric depression: early\u2010onset versus late\u2010onset"],"prefix":"10.1002","volume":"30","author":[{"given":"Amane","family":"Tateno","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Nippon Medical School  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakayori","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Nippon Medical School  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Molecular Imaging 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