{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:46:24Z","timestamp":1790729184334,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"an unrestricted educational grant of Janssen, Belgium"},{"name":"Neurosearch Antwerp; the Research Foundation - Flanders (FWO-Vlaanderen)"},{"name":"the Agency for Innovation by Science and Technology (IWT)"},{"name":"the central Biobank facility of the Institute Born-Bunge \/ University Antwerp"},{"name":"the EU\/EFPIA Innovative Medicines Initiative Joint Undertaking","award":["EMIF grant n\u00c2\u00b0 115372"],"award-info":[{"award-number":["EMIF grant n\u00c2\u00b0 115372"]}]},{"name":"the Foundation for Alzheimer Research (SAO-FRA)"},{"name":"the Institute Born-Bunge"},{"name":"the Interuniversity Attraction Poles (IAP) program of the Belgian Science Policy Office"},{"name":"the Medical Research Foundation Antwerp"},{"name":"the Methusalem excellence grant of the Flemish Government, Belgium"},{"name":"University Research Fund of the University of Antwerp"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Iodine\u2010123 metaiodobenzylguanidine (MIBG) cardiac scintigraphy has shown the potential to discriminate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, these studies did not reflect clinical practice, as patients with ischemic heart disease, heart failure, diabetes mellitus, arterial hypertension, and hyperlipidemia and patients treated with antidepressants like trazodone were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study aimed to evaluate the use of MIBG cardiac scintigraphy to diagnose DLB in clinical practice. Moreover, the potential diagnostic value of MIBG cardiac scintigraphy in patients with clinically ambiguous dementia diagnosis (DLB versus AD) was tested. Eighty\u2010five patients with a possible clinical diagnosis of DLB entered the study. MIBG uptake was determined by calculating the heart\u2010to\u2010mediastinum\u2010uptake ratio (H\/M).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average H\/M ratio was 1.42\u2009\u00b1\u20090.35. The number of core features for DLB and the H\/M ratio were negatively correlated (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.360). With an H\/M ratio cutoff of 1.68 in 20 patients with clinically ambiguous dementia diagnoses (DLB versus AD) at the moment of MIBG cardiac scintigraphy, 95% (19\/20) of the patients were correctly classified as compared with clinical or definite diagnosis at follow\u2010up, with sensitivity and specificity values for diagnosing DLB of 100% (16\/16) and 75% (3\/4), respectively. The H\/M ratio was influenced only by age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.217) and gender (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and not by any other variable studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The MIBG cardiac scintigraphy H\/M ratio is a possible diagnostic biomarker for DLB in routine clinical practice and might have an added diagnostic value in case of doubt between DLB and AD. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.4229","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T07:24:50Z","timestamp":1414999490000},"page":"864-869","source":"Crossref","is-referenced-by-count":36,"title":["Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis"],"prefix":"10.1002","volume":"30","author":[{"given":"Sylvie","family":"Slaets","sequence":"first","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Van Acker","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Network Antwerp (ZNA) Middelheim  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Versijpt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Brussels  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Hauth","sequence":"additional","affiliation":[{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Goeman","sequence":"additional","affiliation":[{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Martin","sequence":"additional","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Paul","family":"De Deyn","sequence":"additional","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"},{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken  Antwerp Belgium"},{"name":"Department of Neurology and Alzheimer Research Center University of Groningen and University Medical Center Groningen (UMCG)  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Engelborghs","sequence":"additional","affiliation":[{"name":"Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born\u2010Bunge University of Antwerp  Antwerp Belgium"},{"name":"Department of Neurology and Memory Clinic Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken  Antwerp 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