{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:43Z","timestamp":1788872383782,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["IRCCS Research Program, Current Research 2009-2011, Line n. 2 \u00e2\u20ac\u0153Malattie complesse\u00e2\u20ac\u009d."],"award-info":[{"award-number":["IRCCS Research Program, Current Research 2009-2011, Line n. 2 \u00e2\u20ac\u0153Malattie complesse\u00e2\u20ac\u009d."]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate in a pilot single\u2010blind randomized controlled clinical trial the efficacy of an integrated treatment with rivastigmine transdermal patch (RTP) and cognitive stimulation (CS) in Alzheimer's disease (AD) patients at 6\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 90 patients with an age \u226565\u2009years admitted to the outpatient Alzheimer's Evaluation Unit with diagnosis of AD. Patients were randomized to enter in the Group\u20101 (RTP\u2009+\u2009CS) or in the Group\u20102 (RTP). All patients at baseline and after 6\u2009months were evaluated with the following tools: Mini Mental State Examination (MMSE), Clinical Dementia Rating (CDR), Hamilton Rating Scale for Depression (HAM\u2010D), Geriatric Depression Scale (GDS\u201015), Neuropsychiatric Inventory (NPI), Neuropsychiatric Inventory\u2010Distress (NPI\u2010D), and a standardized Comprehensive Geriatric Assessment, including also activities of daily living (ADL), instrumental activities of daily living (IADL), and the Mini Nutritional Assessment (MNA). Mortality risk was assessed using the Multidimensional Prognostic Index (MPI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline no significant difference was shown between the two groups. After 6\u2009months of follow\u2010up, there were significant differences between Group\u20101 and Group\u20102 in: MMSE: +6.39% vs. +2.69%, CDR: +6.92% vs. +1.54%, HDRS\u2010D\u2009=\u2009\u221260.7% vs. \u221245.8%, GDS: \u221260.9% vs. \u22127.3%, NPI: \u221255.2% vs. \u221232.7%%, NPI\u2010D: \u221255.1% vs. \u221218.6%, ADL: +13.88% vs. +5.95%, IADL: +67.59% vs. +18.28%, MNA: +12.02% vs. +5.91%, and MPI: \u221229.03% vs. \u221212.90%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The integrated treatment of RTP with CS in AD patients for 6\u2009months improved significantly cognition, depressive and neuropsychiatric symptoms, functional status, and mortality risk in comparison with a group of AD patients receiving only RTP. Copyright \u00a9 2014 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.4247","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T01:02:41Z","timestamp":1418346161000},"page":"965-975","source":"Crossref","is-referenced-by-count":33,"title":["A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease"],"prefix":"10.1002","volume":"30","author":[{"given":"Grazia","family":"D'Onofrio","sequence":"first","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Sancarlo","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Addante","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Cascavilla","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Paris","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Chiara","family":"Elia","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Nuzzaci","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Picoco","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Panza","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"},{"name":"Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs University of Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Geriatric Unit &amp; Laboratory of Gerontology and Geriatrics, Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"},{"name":"Geriatrics Unit  Azienda ULSS 16 Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988707308808"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3823"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.07.001"},{"key":"e_1_2_7_5_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_6_1","first-page":"S346","article-title":"Effective pharmacological management of Alzheimer's disease","volume":"17","author":"Atri A","year":"2011","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004001100018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.151.2.222"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4943(93)90052-J"},{"key":"e_1_2_7_10_1","first-page":"238","article-title":"Mattresses for preventing pressure sores in geriatric patients","volume":"25","author":"Bliss MR","year":"1966","journal-title":"Mon Bull Minist Health Public Health Lab Serv"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930090306"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215505cr911oa"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2004\/085)"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602010443000074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000281846.40390.50"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040223"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/11.3.260"},{"issue":"4","key":"e_1_2_7_19_1","article-title":"Enhancement of therapeutic effects of drug treatment in DAT when combined with cognitive training. Preliminary results of a three month program","volume":"19","author":"De Vreese LP","year":"1998","journal-title":"Neurobiol Aging"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1176\/jnp.15.2.130","article-title":"A critical review of memory stimulation programs in Alzheimer's disease","volume":"15","author":"Grandmaison E","year":"2003","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317510385808"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490510088009"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/10.1_Part_1.20"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02052.x"},{"key":"e_1_2_7_28_1","first-page":"1","article-title":"The clinical significance of cognition\u2010focused interventions for cognitively impaired older adults: a systematic review of randomized controlled trials","volume":"11","author":"Kurz AF","year":"2011","journal-title":"Int Psychogeriatr"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01590.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200407000-00007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610206004194"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X253438"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1980-57642009DN20200011"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_7_36_1","unstructured":"National Institute for Clinical Excellence\/Social Care Institute for Excellence.2006.Dementia. Supporting people with dementia and their carers in health and social care. NICE\/SCIE."},{"key":"e_1_2_7_37_1","first-page":"539","volume-title":"Neuropsiquiatria Geri\u00e1trica","author":"Nomura S","year":"2000"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000147478.03911.28"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000316119"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.5.450"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1304"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e633"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1192\/bjp.bp.113.137414","article-title":"Maintenance cognitive stimulation therapy for dementia: single\u2010blind, multicentre, pragmatic randomised controlled trial","volume":"204","author":"Orrell M","year":"2014","journal-title":"Br J Psychiatry"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb06377.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1975.tb00927.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2007.0569"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp031"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1139"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.865022"},{"key":"e_1_2_7_50_1","first-page":"S5","article-title":"A multidimensional approach to the geriatric patient with chronic kidney disease","volume":"23","author":"Pilotto A","year":"2010","journal-title":"J Nephrol"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","unstructured":"PilottoA RengoF MarchionniN et al.2012.Comparing the prognostic accuracy for all\u2010cause mortality of frailty instruments: a multicentre 1\u2010year follow\u2010up in hospitalized older patients.PLoS ONE7e29090.","DOI":"10.1371\/journal.pone.0029090"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S1355617797004979","article-title":"Learning from our successes and failures. Reflections","volume":"3","author":"Prigatano GP","year":"1997","journal-title":"J Int Neuropsychol Soc"},{"key":"e_1_2_7_53_1","unstructured":"PrinceM BryceC FerriC.2011.World Alzheimer Report 2011: the benefits of early diagnosis and intervention. London (UK). Alzheimer's Disease International (ADI) www.alz.co.uk\/worldreport2011."},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/782959"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095600"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.2.250"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6241-4"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.334"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001119.pub2"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602010143000068"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.183.3.248"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.5.751"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.01.055"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00171-3"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1983.tb01556.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S1355617797004876","article-title":"Cognitive rehabilitation: How it is and how it might be","volume":"3","author":"Wilson B","year":"1997","journal-title":"J Int Neuropsychol Soc"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/09602010244000020"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1788"},{"key":"e_1_2_7_70_1","article-title":"Cognitive stimulation to improve cognitive functioning in people with dementia","volume":"2","author":"Woods B","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1966"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:58:40Z","timestamp":1696471120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/gps.4247"],"URL":"https:\/\/doi.org\/10.1002\/gps.4247","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}