{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:59:46Z","timestamp":1790819986559,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Catalyst Grant Program"},{"name":"Secondary Analysis of Neuroimaging Databases"},{"DOI":"10.13039\/100014041","name":"ADNI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Araclon Biotech"},{"DOI":"10.13039\/100007742","name":"BioClinica, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007742","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Biogen Idec Inc."},{"name":"Bristol-Myers Squibb Company"},{"name":"Eisai Inc."},{"name":"Elan Pharmaceuticals, Inc."},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EuroImmun"},{"DOI":"10.13039\/100004337","name":"F. Hoffmann-La Roche Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004328","name":"Genentech, Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fujirebio"},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"IXICO Ltd."},{"name":"Janssen Alzheimer Immunotherapy Research & Development, LLC"},{"name":"Johnson & Johnson Pharmaceutical Research & Development LLC"},{"name":"Medpace, Inc."},{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Meso Scale Diagnostics, LLC"},{"name":"NeuroRx Research"},{"name":"Neurotrack Technologies"},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004319","name":"Pfizer Inc.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Piramal Imaging"},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Synarc Inc."},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Institutes of Rev, 5 December 2013, Health Research"},{"name":"Canadian Institutes of Health Research Catalyst Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We conducted a neuroimaging analysis to understand the neuroanatomical correlates of gray matter loss in a group of mild cognitive impairment and early Alzheimer's disease patients who developed delusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>With data collected as part of the Alzheimer's Disease Neuroimaging Initiative, we conducted voxel\u2010based morphometry to determine areas of gray matter change in the same Alzheimer's Disease Neuroimaging Initiative participants, before and after they developed delusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 14 voxel clusters with significant gray matter decrease in patient scans post\u2010delusional onset, correcting for multiple comparisons (false discovery rate, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Major areas of difference included the right and left insulae, left precuneus, the right and left cerebellar culmen, the left superior temporal gyrus, the right posterior cingulate, the right thalamus, and the left parahippocampal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although contrary to our initial predictions of enhanced right frontal atrophy, our preliminary work identifies several neuroanatomical areas, including the cerebellum and left posterior hemisphere, which may be involved in delusional development in these patients. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4291","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:36:29Z","timestamp":1427495789000},"page":"76-82","source":"Crossref","is-referenced-by-count":43,"title":["Gray matter atrophy in patients with mild cognitive impairment\/Alzheimer's disease over the course of developing delusions"],"prefix":"10.1002","volume":"31","author":[{"given":"Corinne E.","family":"Fischer","sequence":"first","affiliation":[{"name":"Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"},{"name":"Faculty of Medicine, Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Windsor Kwan\u2010Chun","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto ON Canada"},{"name":"Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen P.","family":"Millikin","sequence":"additional","affiliation":[{"name":"Department of Clinical Health Psychology, College of Medicine, Health Sciences University of Manitoba  Winnipeg MB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom A.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto  Toronto ON Canada"},{"name":"Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto ON Canada"},{"name":"Institute of Biomaterials and Biomedical Engineering University of Toronto  Toronto ON Canada"},{"name":"Division of Neurosurgery, Department of Surgery, Faculty of Medicine University of Toronto  Toronto ON Canada"},{"name":"Division of Neurosurgery St. Michael's Hospital  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Alzheimer Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"ADNI.2015.ADNI study documents(http:\/\/adni.loni.usc.edu\/)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033321"},{"key":"e_1_2_7_4_1","unstructured":"AshburnerJ.2010.VBM tutorial. University College London (http:\/\/www.fil.ion.ucl.ac.uk\/~john\/misc\/VBMclass10.pdf)."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn151"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000338625.47892.74"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.09.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339954"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.12.19"},{"key":"e_1_2_7_10_1","first-page":"268","article-title":"Neuroanatomical correlates of clinical misidentification and misperception in senile dementia of the Alzheimer type","volume":"52","author":"Forstl H","year":"1991","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.165.1.53"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.01.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-011-0195-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.020"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3180cc1fdf"},{"key":"e_1_2_7_17_1","first-page":"25","article-title":"Decreased white matter integrity before the onset of delusions in patients with Alzheimer's disease: diffusion tensor imaging","volume":"9","author":"Nakaaki S","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213000094"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00248-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70158-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2022"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.15.1934"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100048"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.04.015"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205012666150204130456"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211000974"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809141106"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:08:36Z","timestamp":1696392516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/gps.4291"],"URL":"https:\/\/doi.org\/10.1002\/gps.4291","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}