{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:38:51Z","timestamp":1775687931173,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AG031272"],"award-info":[{"award-number":["R01-AG031272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AG011380"],"award-info":[{"award-number":["R01-AG011380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32-AG000029"],"award-info":[{"award-number":["T32-AG000029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Utah Huntsman Cancer Institute and the Huntsman Cancer Institute Cancer Center Support","award":["P30 CA42014"],"award-info":[{"award-number":["P30 CA42014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Parental death during childhood, and offspring and spouse death during adulthood have individually been associated with faster cognitive decline and higher Alzheimer's disease (AD) risk in late life. However, the cumulative effect of childhood and adulthood family deaths on AD risk among different age cohorts has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To examine these associations, this prospective cohort study uses a population\u2010based sample of 4545 initially non\u2010demented participants (56.7% female; age M\u2009=\u200975.0\/SD\u2009=\u20096.9\u2009years) observed at four triennial waves, linked with objective Utah Population Database data on cumulative mother, father, sibling, spouse, and offspring death experienced during childhood and adulthood. Cox regression modeled survival time from baseline interview to AD onset, as a function of family deaths during childhood or adulthood, among different age groups, along with gender and presence of \u03b54 allele at apolipoprotein E (APOE) polymorphic genetic locus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age group significantly moderated the relationship between family death and AD; among persons aged 65\u201369\u2009years at baseline (children of the Great Depression), those exposed to 3\u20134 deaths and 5+ deaths during adulthood exhibited a doubling of AD risk (adjusted hazard ratio, aHR\u2009=\u20092.25, <jats:italic>p<\/jats:italic>\u2009=\u2009.038, and aHR\u2009=\u20092.72, <jats:italic>p<\/jats:italic>\u2009=\u2009.029), while among persons aged 80\u2009years and older, those exposed to 3\u20134 deaths during adulthood exhibited lower AD risk (HR\u2009=\u20090.539, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). In a combined model of childhood and adulthood deaths, these findings persisted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest a cohort effect in the link between family member deaths during adulthood and AD risk later in life. 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