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Individuals aged 60\u2009years and older were diagnosed with major depressive disorder at time of assessment (<jats:italic>N<\/jats:italic>\u2009=\u2009173). All participants received clinical assessment of depression and completed neuropsychological testing during a depressive episode. Physical frailty was assessed using an adaptation of the FRAIL scale. Neuropsychological domains were derived from a factor analysis that yielded three factors: (i) speeded executive and fluency, (ii) episodic memory, and (iii) working memory. Associations were examined with bivariate tests and multivariate models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Depressed individuals with a FRAIL score &gt;1 had worse performance than nonfrail depressed across all three factors; however, speeded executive and fluency was the only factor that remained significant after controlling for depression symptom severity and demographic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although physical frailty is associated with broad neurocognitive deficits in LLD, it is most robustly associated with deficits in speeded executive functions and verbal fluency. Causal inferences are limited by the cross\u2010sectional design, and future research would benefit from a comparison group of nondepressed older adults with similar levels of frailty. Research is needed to understand the mechanisms underlying associations among depression symptoms, physical frailty, and executive dysfunction and how they are related to the cognitive and symptomatic course of LLD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4351","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T19:24:05Z","timestamp":1440703445000},"page":"466-474","source":"Crossref","is-referenced-by-count":36,"title":["Physical frailty in late\u2010life depression is associated with deficits in speed\u2010dependent executive functions"],"prefix":"10.1002","volume":"31","author":[{"given":"Guy G.","family":"Potter","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Duke University School of Medicine  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"McQuoid","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences 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