{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:40:58Z","timestamp":1791945658868,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005632","name":"Forest Laboratories","doi-asserted-by":"publisher","award":["NAM\u2010MD\u201033; NCT01876823"],"award-info":[{"award-number":["NAM\u2010MD\u201033; NCT01876823"]}],"id":[{"id":"10.13039\/100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study is to assess combined antidepressant and memantine treatment in older patients presenting with depression and cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five depressed patients with cognitive impairment participated in this open\u2010label pilot study. We evaluated whether, over a 48\u2010week period, combined antidepressant (primarily es\u2010citalopram) and memantine treatment was effective in the treatment of cognitive impairment and depression. Neuropsychological testing was performed, and antidepressant response monitored at baseline and at the 12, 24, and 48\u2010week time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with escitalopram (mean daily dose 18.62\u2009mg, SD 5.15) and memantine (mean daily dose 13.62\u2009mg, SD 6.67) was associated with improvement in Hamilton Depression Rating Scale scores over the 48\u2010week study period. Patients demonstrated significant improvement in the primary outcome of cognitive performance (Selective Reminding Test total immediate recall; SRT\u2010IR) over the 48\u2010week treatment period (<jats:italic>p<\/jats:italic>\u2009=\u20090.0147). Significant improvement was also observed in measures of naming and verbal fluency but not in the other cognitive domains. One of the 35 patients (2.9%) converted to Alzheimer's disease over the 48\u2010week treatment period. In the amnestic mild cognitive impairment subsample (<jats:italic>n<\/jats:italic>\u2009=\u200922), the conversion rate was 4.5%, a rate lower than in other reports of patients with DEP\u2010CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this open\u2010label trial, combined antidepressant and memantine treatment in patients with DEP\u2010CI was associated with improved cognition and a low rate of conversion to dementia compared with published studies in patients with DEP\u2010CI. Although limited by the open\u2010label study design that incorporates practice effects that can improve cognitive test performance, the findings suggest the need for a larger randomized placebo\u2010controlled trial. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4375","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T02:14:41Z","timestamp":1447294481000},"page":"648-655","source":"Crossref","is-referenced-by-count":29,"title":["Combined treatment with memantine\/es\u2010citalopram for older depressed patients with cognitive impairment: a pilot study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-9160","authenticated-orcid":false,"given":"Gregory H.","family":"Pelton","sequence":"first","affiliation":[{"name":"Late Life Depression Clinic, The Memory Disorders Center, and The Division of Geriatric Psychiatry New York State Psychiatric Institute  New York NY USA"},{"name":"The College of Physicians and Surgeons of Columbia University  New York NY USA"},{"name":"Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center Columbia University College of Physicians and Surgeons  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver L.","family":"Harper","sequence":"additional","affiliation":[{"name":"The College of Physicians and Surgeons of Columbia University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Roose","sequence":"additional","affiliation":[{"name":"Late Life Depression Clinic, The Memory Disorders Center, and The Division of Geriatric Psychiatry New York State Psychiatric Institute  New York NY USA"},{"name":"The College of Physicians and Surgeons of Columbia University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Marder","sequence":"additional","affiliation":[{"name":"The College of Physicians and Surgeons of Columbia University  New York NY USA"},{"name":"Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. 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