{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T21:09:43Z","timestamp":1723842583341},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"publisher","award":["0701\u2013065"],"award-info":[{"award-number":["0701\u2013065"]}],"id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Depression is associated with an increased risk of cognitive decline. The present study compared two\u2010year change in cognitive performance between depressed older persons and a non\u2010depressed control group, between remitted and non\u2010remitted patients, and evaluated whether vascular burden at baseline was associated with more cognitive decline in depressed older persons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Depressed patients (<jats:italic>n<\/jats:italic>\u2009=\u2009378) aged \u226560 were recruited from mental healthcare institutes and general practices, and a non\u2010depressed control group (<jats:italic>n<\/jats:italic>\u2009=\u2009132) was recruited from general practices. A DSM\u2010IV depressive episode was established with the Composite International Diagnostic Interview, and processing speed, working memory, verbal memory and interference control were evaluated with three neurocognitive tasks at baseline and 2\u2009years later. A modified Framingham Risk Score, ankle\u2010brachial index, and history of a vascular event defined vascular burden at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for baseline cognitive performance, age, sex, and education level, depressed older persons had worse processing speed and verbal memory scores at follow\u2010up than controls (regression coefficients: \u22120.172; <jats:italic>p<\/jats:italic>\u2009=\u20090.042 and \u22120.309; <jats:italic>p<\/jats:italic>\u2009=\u20090.001, respectively) but did not differ in the other two\u2010cognitive outcomes. In the sample of depressed patients, remission status at 2\u2009years follow\u2010up and baseline vascular burden did not predict cognitive performance at follow\u2010up, after adjustment for baseline cognitive performance, age, sex and education level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that cognitive deficits in depressed older persons are not just a manifestation of depression. In addition, vascular burden was not associated with worse cognitive decline in a sample of depressed older persons. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4416","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:41:27Z","timestamp":1453768887000},"page":"1029-1039","source":"Crossref","is-referenced-by-count":5,"title":["Cognitive performance in depressed older persons: the impact of vascular burden and remission. A two\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"31","author":[{"given":"Marij","family":"Zuidersma","sequence":"first","affiliation":[{"name":"University Center of Psychiatry &amp; Interdisciplinary Center Psychopathology and Emotion Regulation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannie C.","family":"Comijs","sequence":"additional","affiliation":[{"name":"Department of Psychiatry\/EMGO Institute for Care and Research VU University Medical Center  Amsterdam The Netherlands"},{"name":"GGZ inGeest  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Naarding","sequence":"additional","affiliation":[{"name":"Department of Old Age Psychiatry GGNet Center for Mental Health  Apeldoorn The Netherlands"},{"name":"Department of Psychiatry Radboud University Medical Center Nijmegen  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Oude Voshaar","sequence":"additional","affiliation":[{"name":"University Center of Psychiatry &amp; Interdisciplinary Center Psychopathology and Emotion Regulation University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.4.562"},{"key":"e_1_2_8_3_1","unstructured":"American Psychiatric Association.1994.Diagnostic and statistic manual of mental disorders. 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