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Asymptomatic A\u03b2 deposition has been reported consistently in some healthy older subjects. Of patients with frontotemporal dementia, those who have later onset have a higher potential for A\u03b2 deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Comparison of A\u03b2 deposition in Alzheimer's disease (AD), healthy older controls, and patients with early\u2010 and late\u2010onset semantic dementia (SD), a subtype of frontotemporal dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were recruited from tertiary academic care centers specializing in assessment and management of patients with neurodegenerative disease. We used the radiotracer [11C]\u2010PIB in a high\u2010resolution positron emission tomography scanner to evaluate 11 participants with SD (six with onset before age 65 and five with later onset), 9 with probable AD, and 10 controls over age 60. The main outcome measures were frontal, temporal, parietal, and total [11C]\u2010PIB standardized uptake value ratios to establish PIB\u2010positive (PIB+) cutoff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The five patients with late\u2010onset SD were PIB\u2010negative. Two of six with early\u2010onset SD, seven of nine with AD, and 1 of 10 controls were PIB+. The SD participants who were PIB+ did not have memory or visuospatial deficits that are typical in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A\u03b2 deposition does not seem to be associated with late\u2010onset SD. Future larger studies might confirm whether a significant minority of early\u2010onset SD patients exhibit A\u03b2 deposition. 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