{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:27:58Z","timestamp":1791084478457,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Age\u2010related white matter lesions (ARWMLs) have been identified in various clinical conditions such as reduced gait speed, cognitive impairment, urogenital dysfunction, and mood disturbances. Previous studies indicated an association between ARWML and late\u2010onset major depression. However, most of these focused on the extent of supratentorial ARWML and neglected presence and degree of infratentorial lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 45 patients (mean age 73.7\u2009\u00b1\u20096.3\u2009years, 17 (37.8%) men, 28 (62.2%) women) with late\u2010onset major depression, MRI findings (3.0\u2010T MR system, Magnetom Trio, Siemens Medical Systems, Erlangen, Germany) were analyzed with emphasis on the extent of supratentorial and infratentorial, as well as brainstem ARWMLs, and compared with control subjects. ARWMLs were determined by semiquantitative rating scales (modified Fazekas rating scale, Scheltens' rating scale), as well as a semiautomatic volumetric assessment, using a specific software (MRIcron). Supratentorial and infratentorial, as well as brainstem ARWMLs, were assessed both on fluid attenuated inversion recovery and T2\u2010weighted images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with late\u2010onset major depression had significantly higher infratentorial ARWML rating scores (5 (5\u20137) vs 4.5 (3\u20136), <jats:italic>p<\/jats:italic>\u2009=\u20090.003) on T2\u2010weighted images and volumes (1.58\u2009\u00b1\u20091.35\u2009mL vs 1.05\u2009\u00b1\u20090.81\u2009mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) on T2\u2010weighted images, as well as fluid attenuated inversion recovery images (2.07\u2009\u00b1\u20091.35\u2009mL vs 1.52\u2009\u00b1\u20091.10\u2009mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.04), than normal controls. In more detail, in particular, the pontine ARWML rating subscore was significantly higher in patients with late\u2010onset major depression (1 (1\u20132) vs 1 (1\u20131), <jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extent and localization of brainstem ARWML might be of importance for the pathophysiology of late\u2010onset major depression. In particular, this may hold true for pontine ARWML. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4487","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T21:31:18Z","timestamp":1461706278000},"page":"446-454","source":"Crossref","is-referenced-by-count":7,"title":["Late\u2010onset major depression is associated with age\u2010related white matter lesions in the brainstem"],"prefix":"10.1002","volume":"32","author":[{"given":"Johannes","family":"Schwichtenberg","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Al\u2010Zghloul","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Universit\u00e4tsmedizin Mannheim Medical Faculty Mannheim University of Heidelberg  Mannheim 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