{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:18:55Z","timestamp":1759033135515},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The generalizability of antidepressant efficacy trials (AETs) has been questioned. No studies have examined the inclusion\/exclusion criteria used in placebo\u2010controlled studies of late life depression and compared them to the criteria used in non\u2010late life AETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a comprehensive literature review of placebo\u2010controlled AETs published from January, 1995 through December, 2014. We compared the inclusion\/exclusion criteria used in the 18 studies of late life depression to those used in non\u2010late life depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were nine inclusion\/exclusion criteria that were used in more than half of the late life depression AETs: minimum severity on a symptom severity scale (100.0%), significant suicidal ideation (77.8%), psychotic features during the current episode of depression or history of a psychotic disorder (94.4%), history of bipolar disorder (77.8%), diagnosis of alcohol or drug abuse or dependence (83.3%), presence of a comorbid nondepressive, nonsubstance use Axis I disorder (55.6%), episode duration too short (66.7%), and an insufficient score on a cognitive screen (88.3%) or the presence of a cognitive disorder (55.6%). There were some differences between the late life and non\u2010late life depression studies\u2014use of a screening measure of cognitive functioning, presence of a cognitive disorder such as dementia, and the minimum depression severity cutoff score required at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The inclusion\/exclusion criteria in AETs of late life depression were generally similar to the criteria used in non\u2010late life depression AETs. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4560","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T10:46:43Z","timestamp":1471862803000},"page":"1009-1016","source":"Crossref","is-referenced-by-count":5,"title":["Inclusion\/exclusion criteria in late life depression antidepressant efficacy trials"],"prefix":"10.1002","volume":"32","author":[{"given":"Mark","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Human Behavior, Brown Medical School Department of Psychiatry Rhode Island Hospital  Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Multach","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, Brown Medical School Department of Psychiatry Rhode Island Hospital  Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather 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