{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:22:40Z","timestamp":1787239360616,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian HIV Trials Network, Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CHL\u2010126215"],"award-info":[{"award-number":["CHL\u2010126215"]}],"id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Many patients with bipolar disorder are reaching old age, but whether they are receiving evidence\u2010based psychotropic treatment remains unclear. Our objective was to describe current psychotropic prescribing patterns in a large Canadian late\u2010life bipolar sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Population\u2010based cross\u2010sectional study of 1443 bipolar disorder patients aged\u2009\u2265\u200966, discharged from a psychiatric hospitalization in Ontario, Canada from 1 April 2006 to 31 March 2012. We described psychotropic medication prescribing within 30\u2009days post\u2010discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prescription of \u22652 psychotropic medications was highly prevalent (81.5%). The most common medications were atypical antipsychotics (75.3%), benzodiazepines\/zopiclone (42.3%), and antidepressants (38.5%), with less frequent use of valproate (35.4%) and lithium (23.4%). Only 1.4% of patients were on lithium monotherapy, while 4.4% and 15.7% of patients were on antidepressant or atypical antipsychotic monotherapy; 8.9% of all patients were using \u22652 atypical antipsychotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In clinical practice, older adults hospitalized with bipolar disorder are often prescribed multiple psychotropic medications upon discharge. In many instances, practices did not reflect bipolar treatment guidelines and may be putting patients at risk for poor physical health and psychiatric outcomes. One such example is the very infrequent use of lithium monotherapy. Future research should examine whether health system\u2010wide protocolized late\u2010life bipolar treatment may optimize prescribing to improve effectiveness and safety. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.4635","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T07:12:13Z","timestamp":1480662733000},"page":"1459-1465","source":"Crossref","is-referenced-by-count":35,"title":["Current psychotropic medication prescribing patterns in late\u2010life bipolar disorder"],"prefix":"10.1002","volume":"32","author":[{"given":"Soham","family":"Rej","sequence":"first","affiliation":[{"name":"Division of Geriatric Psychiatry, Department of Psychiatry, Sunnybrook Health Sciences Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry, Department of Psychiatry, Sunnybrook Health Sciences Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Shulman","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry, Department of Psychiatry, Sunnybrook Health Sciences Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas D.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinwah","family":"Fung","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences  Toronto Canada"},{"name":"Women's College Research Institute Women's College Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gruneir","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences  Toronto Canada"},{"name":"Women's College Research Institute Women's College Hospital  Toronto Canada"},{"name":"Institute for Health Policy, Management and Evaluation University of Toronto  Toronto Canada"},{"name":"Department of Family Medicine University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318187135f"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.1.85"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/11587810-000000000-00000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212444"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-10-80"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4534"},{"key":"e_1_2_7_8_1","unstructured":"DuerdenM. AveryT.&PayneR.2013Polypharmacy and medicines optimisation: making it safe and sound. The King's Fund."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610209008667"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61828-6"},{"key":"e_1_2_7_11_1","first-page":"819","article-title":"Maintenance treatment study designs in bipolar disorder: do they demonstrate that atypical neuroleptics (antipsychotics) are mood stabilizers?","volume":"25","author":"Goodwin FK","year":"2011","journal-title":"CNS Drugs"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1013"},{"key":"e_1_2_7_13_1","unstructured":"Information CIfH.2014.Ontario Mental Health Reporting System Resource Manual 2013\u20132014."},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"Associations of medical comorbidity, psychosis, pain, and capacity with psychiatric hospital length of stay in geriatric inpatients with and without dementia","author":"Ismail Z","year":"2014","journal-title":"Int psychogeriatr\/IPA"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.084822"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/03602530902722679"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13070984"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2850.2009.01429.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4128"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398506"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-13-15"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04912gre"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.01.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-014-0234-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-58"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12331"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/ps.2007.58.6.855"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.07.006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371205700906"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7396.960"},{"key":"e_1_2_7_32_1","first-page":"3","article-title":"[Clinical concepts associated with lithium underutilization in the treatment of bipolar disorder]","volume":"22","author":"Strejilevich SA","year":"2011","journal-title":"Vertex"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15050618"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.12.2099"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13111501"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12025"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00779.x"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:43:43Z","timestamp":1695476623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,2]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/gps.4635"],"URL":"https:\/\/doi.org\/10.1002\/gps.4635","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,2]]}}}