{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:38:51Z","timestamp":1787510331873,"version":"build-2736575974"},"reference-count":165,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Centers for Disease Control and Prevention's (CDC) Healthy Aging Program","award":["U48-DP000050"],"award-info":[{"award-number":["U48-DP000050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The challenges posed by people living with multiple chronic conditions are unique for people with dementia and other significant cognitive impairment. There have been recent calls to action to review the existing literature on co\u2010occurring chronic conditions and dementia in order to better understand the effect of cognitive impairment on disease management, mobility, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic literature review searched PubMed databases through 2011 (updated in 2016) using key constructs of older adults, moderate\u2010to\u2010severe cognitive impairment (both diagnosed and undiagnosed dementia), and chronic conditions. Reviewers assessed papers for eligibility and extracted key data from each included manuscript. An independent expert panel rated the strength and quality of evidence and prioritized gaps for future study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four thousand thirty\u2010three articles were identified, of which 147 met criteria for review. We found that moderate\u2010to\u2010severe cognitive impairment increased risks of mortality, was associated with prolonged institutional stays, and decreased function in persons with multiple chronic conditions. There was no relationship between significant cognitive impairment and use of cardiovascular or hypertensive medications for persons with these comorbidities. Prioritized areas for future research include hospitalizations, disease\u2010specific outcomes, diabetes, chronic pain, cardiovascular disease, depression, falls, stroke, and multiple chronic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review summarizes that living with significant cognitive impairment or dementia negatively impacts mortality, institutionalization, and functional outcomes for people living with multiple chronic conditions. Our findings suggest that chronic\u2010disease management interventions will need to address co\u2010occurring cognitive impairment. Copyright \u00a9 2017 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.4652","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T11:44:32Z","timestamp":1485949472000},"page":"357-371","source":"Crossref","is-referenced-by-count":76,"title":["Dementia and co\u2010occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?"],"prefix":"10.1002","volume":"32","author":[{"given":"Mark B.","family":"Snowden","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington School of Medicine Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley E.","family":"Steinman","sequence":"additional","affiliation":[{"name":"Health Promotion Research Center University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda 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