{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:16:38Z","timestamp":1777482998209,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373000"],"award-info":[{"award-number":["81373000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Several studies have shown that gout is associated with depression symptoms. In this study, a systematic review and meta\u2010analysis was performed to explore the relationship between gout and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Published articles were identified through a comprehensive review of PUBMED and EMBASE. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of depression among participants who had gout versus those without gout were analyzed. A random\u2010effect model was used to calculate pooled odds ratios and 95% confident intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies, which included 411\u00a0745 participants, aligned with our inclusion criteria and were included in the meta\u2010analysis. Pooled analysis showed an association between gout and depression, with an odds ratio of 1.19 (95%CI, 1.11, 1.29; <jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u00a0=\u00a060.2%). Subgroup\u2010analysis adjusted (or not) by study type or study quality showed a statistically significant association of gout and depression in all subgroups. Sensitivity analysis by 1\u2010study removed analysis, excluding articles of self\u2010reported gout assessment or male\u2010only, confirmed the robustness of our results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis demonstrates a positive association between gout and depression. Further large\u2010scale prospective cohort studies are needed to investigate the causality between gout and depression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4789","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:40:20Z","timestamp":1505745620000},"page":"441-448","source":"Crossref","is-referenced-by-count":22,"title":["Association of gout and depression: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-7217","authenticated-orcid":false,"given":"Song","family":"Lin","sequence":"first","affiliation":[{"name":"The College of Public Health Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The College of Public Health Qingdao University  Qingdao 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