{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:27:10Z","timestamp":1761060430312,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH083660","P30 MH90333","R34 MH101371"],"award-info":[{"award-number":["R01 MH083660","P30 MH90333","R34 MH101371"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","award":["R01 MH083648"],"award-info":[{"award-number":["R01 MH083648"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009608","name":"Western Washington University","doi-asserted-by":"publisher","award":["R01 MH083643","R34 MH101365"],"award-info":[{"award-number":["R01 MH083643","R34 MH101365"]}],"id":[{"id":"10.13039\/100009608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","award":["T32 MH019986"],"award-info":[{"award-number":["T32 MH019986"]}],"id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify which specific depressive symptoms predict remission to aripiprazole augmentation in late\u2010life treatment resistant depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a secondary analysis of data from a late\u2010life treatment resistant depression trial examining the safety and efficacy of aripiprazole augmentation. Participants aged 60 and above were randomized to aripiprazole augmentation (N\u00a0=\u00a091) versus placebo (N\u00a0=\u00a090). The main outcome was depression remission. Clinical predictors included individual Montgomery\u2010Asberg Depression Rating Scale (MADRS) item scores categorized as symptomatic (scores &gt;2) or nonsymptomatic (scores \u22642).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three MADRS items predicted depression remission with aripiprazole augmentation: symptomatic scores on sleep disturbance and nonsymptomatic scores on apparent sadness and inability to feel. The 2\u2010way and 3\u2010way interaction terms of these MADRS items were not significant predictors of remission; therefore, the models' ability to predict remission was not improved by combining the significant MADRS items.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The identification of specific depressive symptoms, which can be clinically assessed, can be used to inform treatment decisions. Older adults with treatment resistant depression that present with sleep disturbances, lack of apparent sadness, or lack of inability to feel should be considered for aripiprazole augmentation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4813","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T03:50:03Z","timestamp":1507089003000},"source":"Crossref","is-referenced-by-count":8,"title":["Specific depressive symptoms predict remission to aripiprazole augmentation in late\u2010life treatment resistant depression"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1711-3306","authenticated-orcid":false,"given":"Marie Anne","family":"Gebara","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh PA USA"},{"name":"Mental Illness Research, Education and Clinical Center VA Pittsburgh Healthcare System  Pittsburgh PA 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