{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:48:54Z","timestamp":1785422934389,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of pain treatment on sleep in nursing home (NH) patients with dementia and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, 2\u2010armed, double\u2010blinded, placebo\u2010controlled, randomized clinical trial conducted between August 2014 and September 2016. One hundred six long\u2010term patients from 47 NHs in Norway with dementia and depression according to the <jats:italic>Mini\u2010Mental State Examination<\/jats:italic> and the <jats:italic>Cornell Scale for Depression in Dementia<\/jats:italic> were included. Patients received stepwise pain treatment in which those who did not use analgesics were randomized to receive either paracetamol (3\u00a0g\/day) or placebo tablets; those who already used pain treatment were allocated to buprenorphine transdermal system (max. 10\u00a0\u03bcg\/h\/7\u00a0days) or placebo transdermal patches. Sleep was assessed continuously for 14\u00a0days by actigraphy, 1\u00a0week of baseline measurement, and 1\u00a0week of ongoing treatment. The following sleep parameters were evaluated: total sleep time, sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset, early morning awakening (EMA), and number of wake bouts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the intervention group (paracetamol\/buprenorphine), SE (70%\u201072%), SOL (32\u201024\u00a0min), and EMA (50\u201040\u00a0min) improved compared with the control group (SE, 70%\u201067%; SOL, 47\u201060\u00a0min; EMA, 31\u201035\u00a0min). Treatment effects were significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05, and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with placebo, pain treatment improved sleep as measured with actigraphy. This implies that sleep, pain, and depression in NH patients should be critically evaluated and that pain treatment should be considered to be a potentially beneficial treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4839","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T08:03:54Z","timestamp":1514448234000},"page":"663-670","source":"Crossref","is-referenced-by-count":31,"title":["Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo\u2010controlled randomized clinical trial"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-7343","authenticated-orcid":false,"given":"Kjersti Marie","family":"Blytt","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen  Bergen Norway"},{"name":"Centre for Elderly and Nursing Home Medicine University of Bergen  Bergen Norway"},{"name":"Norwegian 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