{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:29:07Z","timestamp":1789439347597,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006388","name":"H\u00f4pitaux Universitaires de Gen\u00e8ve","doi-asserted-by":"publisher","award":["PRD 11\u2010I\u20103 and PRD 12\u20102013\u2010I"],"award-info":[{"award-number":["PRD 11\u2010I\u20103 and PRD 12\u20102013\u2010I"]}],"id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Apathy\u2014the most common behavioral disturbance in idiopathic normal pressure hydrocephalus (iNPH)\u2014is associated with poor gait, but the role of apathy on gait improvement after cerebrospinal fluid (CSF) tapping has not been studied yet. This study aims to compare gait improvement after CSF tapping in iNPH patients with and without apathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stride time variability (STV), a marker of higher level of gait control, was measured in 33 iNPH patients (78.4\u00a0\u00b1\u00a05.7\u00a0years; 36.4% women) with an optoelectronic system during usual walking (single task) and during walking while dual tasking of counting and verbal fluency before and 24\u00a0hours after CSF tapping. Apathy was defined by a score \u226514 on the Starkstein apathy scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apathy was present in 60.6% of patients. Cerebrospinal fluid tapping led to greater improvement of STV (ie, decrease) during dual\u2010task walking (and more specifically categorical verbal fluency) in apathetic compared to nonapathetic patients (\u221244.7\u00a0\u00b1\u00a058.1% versus +4.24\u00a0\u00b1\u00a067.6%, respectively; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.040), even after adjusting for age and depressive symptoms. More severe apathy was correlated with better STV improvement while dual tasking (categorical verbal fluency) after CSF tapping (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.412; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.021), while it was not correlated with improvement on executive tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that the presence of apathy is a predictor of better outcomes of gait disorders after CSF tapping in patients with iNPH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4847","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T09:32:47Z","timestamp":1514885567000},"page":"735-742","source":"Crossref","is-referenced-by-count":14,"title":["Apathy in idiopathic normal pressure hydrocephalus: A marker of reversible gait disorders"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-6719","authenticated-orcid":false,"given":"Gilles","family":"Allali","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine University of Geneva  Geneva Switzerland"},{"name":"Department of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine Yeshiva University  Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Laidet","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Armand","sequence":"additional","affiliation":[{"name":"Willy Taillard Laboratory of Kinesiology Geneva University Hospitals and University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Saj","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Krack","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Assal","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospitals and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00019-8"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"38","article-title":"Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus","volume":"30","author":"Peterson KA","year":"2016","journal-title":"Br J Neurosurg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2016.12.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-2-19"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.08.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51516.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0237"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2017.06.001"},{"issue":"3","key":"e_1_2_8_10_1","article-title":"Diagnosing idiopathic normal\u2010pressure hydrocephalus","volume":"57","author":"Relkin N","year":"2005","journal-title":"Neurosurgery"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.20.2.215"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7442-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.4.2.134"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31823038f2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12779"},{"key":"e_1_2_8_18_1","unstructured":"D'EliaLF SatzP UchiyamaCL WhiteT.Color Trail Test. 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