{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:11:31Z","timestamp":1768885891917,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000355","name":"Bupa Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Neuropsychiatric symptoms such as agitation and delusions occur frequently in Lewy body dementia and Alzheimer's disease and represent significant burden and unmet treatment need. The underlying aetiology remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a multidimensional linear model to look for associations between measurements of agitation, delusions, amyloid, tau and \u03b1\u2010synuclein pathology, and synaptic proteins (ZnT3, PSD95, synaptophysin, and \u03b2\u2010III\u2010tubulin) across multiple brain regions in post\u2010mortem tissue from a cohort of 130 Lewy body dementia and Alzheimer's disease patients and non\u2010demented controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found both agitations and delusions to be significantly associated with increased tau pathology and decreased levels of ZnT3. ZnT3 packages Zn<jats:sup>2+<\/jats:sup> into synaptic vesicles to be released as a long\u2010term modulator of synaptic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our finding adds to the evidence that zinc modulating compounds are of interest for treatment or symptomatic relief in these dementias.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4908","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T09:38:28Z","timestamp":1527845908000},"page":"1146-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between ZnT3, tau pathology, agitation, and delusions in dementia"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9792","authenticated-orcid":false,"given":"David R.","family":"Whitfield","sequence":"first","affiliation":[{"name":"Wolfson Centre for Age\u2010Related Diseases Institute of 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