{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:58:42Z","timestamp":1780606722155,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG040093\u201001"],"award-info":[{"award-number":["R01AG040093\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairment (CI) represent a unique, understudied population. Our aim was to examine baseline characteristics of DEP\u2010CI patients in the DOTCODE trial, a randomized controlled trial of open antidepressant treatment for 16\u00a0weeks followed by add\u2010on donepezil or placebo for 62\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Design<\/jats:title><jats:p>Key inclusion criteria were diagnosis of major depression or dysthymic disorder with Hamilton Depression Rating Scale (HAM\u2010D) score &gt;14, and cognitive impairment defined by MMSE score \u226521 and impaired performance on the WMS\u2010R Logical Memory II test. Patients were classified as EMCI or LMCI based on the 1.5 SD cutoff on tests of verbal memory, and compared on baseline clinical, neuropsychological, and anatomical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine DEP\u2010CI patients were recruited of whom 39 met criteria for EMCI and 40 for LMCI. The mean age was 68.9, and mean HAM\u2010D was 23.0. Late mild cognitive impairment patients had significantly worse ADAS\u2010Cog (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), MMSE (<jats:italic>P<\/jats:italic> = .004), Block Design (<jats:italic>P<\/jats:italic> = .024), Visual Rep II (<jats:italic>P<\/jats:italic> = .006), CFL Animal (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), UPSIT (<jats:italic>P<\/jats:italic> = .051), as well as smaller right hippocampal volume (<jats:italic>P<\/jats:italic> = .037) compared to EMCI patients. MRI indices of cerebrovascular disease did not differ between EMCI and LMCI patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cognitive and neuronal loss markers differed between EMCI and LMCI among patients with DEP\u2010CI, with LMCI being more likely to have the clinical and neuronal loss markers known to be associated with Alzheimer's disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4955","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T09:34:18Z","timestamp":1532338458000},"page":"1604-1612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-3424","authenticated-orcid":false,"given":"Jeffrey N.","family":"Motter","sequence":"first","affiliation":[{"name":"The Graduate Center City University of New York  New York NY USA"},{"name":"Queens College City University of New York  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Pelton","sequence":"additional","affiliation":[{"name":"Columbia University  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"D'Antonio","sequence":"additional","affiliation":[{"name":"Columbia University  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N.","family":"Rushia","sequence":"additional","affiliation":[{"name":"The Graduate Center City University of New York  New York NY USA"},{"name":"Queens College City University of New York  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2775-7735","authenticated-orcid":false,"given":"Monique A.","family":"Pimontel","sequence":"additional","affiliation":[{"name":"The Graduate Center City University of New York  New York NY USA"},{"name":"Queens College City University of New York  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Petrella","sequence":"additional","affiliation":[{"name":"Duke University  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Garcon","sequence":"additional","affiliation":[{"name":"Columbia University  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela W.","family":"Ciovacco","sequence":"additional","affiliation":[{"name":"Columbia University  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel R.","family":"Sneed","sequence":"additional","affiliation":[{"name":"The Graduate Center City University of New York  New York NY USA"},{"name":"Queens College City University of New York  New York NY USA"},{"name":"Columbia University  New York NY USA"},{"name":"New York State Psychiatric Institute  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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