{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:41:01Z","timestamp":1790617261601,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>As for the association between orthostatic hypotension (OH) and dementia, results of published studies are inconsistent; therefore, current substantive conclusions have yet been obtained. This meta\u2010analysis was conducted in hopes of producing progress in this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic database search was performed towards electronic databases including Chinese Biomedical Database, PubMed, Web of Science, Wiley Online Library, ScienceDirect, and the Cochrane Library. Five prospective cohort studies were included. Summary hazard ratio (HR) estimates with 95% confidence intervals (CIs) were calculated by random\u2010effects model. Statistical heterogeneity was assessed with the Cochran <jats:italic>Q<\/jats:italic> test and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic. A sensitivity analysis was also conducted in this meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 22.4% higher prevalence of dementia in subjects with OH was obtained (adjusted pooled HR was 1.224; 95% CI: 1.106\u20101.354; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). This meta\u2010analysis also showed significant associations between OH and 2 dementia subtypes: Alzheimer disease (adjusted pooled HR was 1.175; 95% CI: 1.022\u20101.351; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023) and Vascular dementia (adjusted pooled HR was 1.403; 95% CI: 1.042\u20101.889; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Orthostatic hypotension is positively associated with the overall prevalence of dementia, and it may contribute to the prevalence of Alzheimer disease and Vascular dementia as well.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4964","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T13:52:48Z","timestamp":1537797168000},"page":"1541-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The association between orthostatic hypotension and dementia: A meta\u2010analysis of prospective cohort studies"],"prefix":"10.1002","volume":"33","author":[{"given":"Min","family":"Min","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Sun","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-8059","authenticated-orcid":false,"given":"Yehuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University  Hefei Anhui China"},{"name":"Centre for Evidence\u2010Based Practice Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"1470","article-title":"The Consensus Committee of the American Autonomic Society and the American Academy of Neurology","volume":"46","author":"Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy","year":"1996","journal-title":"Neurol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8375-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70088-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2011.08.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv093"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.01.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.188151"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1686-8"},{"key":"e_1_2_9_11_1","unstructured":"World Health Organization. Dementia: a public health priority.2012. Available:http:www.who.int\/mental_health\/publications\/dementia_report_2012\/en\/(Accessed December 22 2017)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31460-X"},{"key":"e_1_2_9_13_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta\u2010analyses.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.html"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09048"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0228-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002143"},{"issue":"28","key":"e_1_2_9_20_1","article-title":"Abstract 28: orthostatic hypotension is associated with 20\u2010year cognitive decline and incident dementia: The Atherosclerosis Risk in Communities (ARIC) Study","volume":"135","author":"Andreea Rawlings SJGH","year":"2017","journal-title":"Circulation"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S72316"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly061"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12592"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq068"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106629"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-016-0340-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000255459"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07334"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000160955"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317512466692"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00121"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13596"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.056"},{"key":"e_1_2_9_34_1","article-title":"Inter\u2010relations of orthostatic blood pressure change, aorticstiffness, and brain structure and function in young adults","volume":"6","author":"Cooper LL","year":"2017","journal-title":"Am HeartAssoc"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","unstructured":"SoennesynH NilsenDW OppedalK et al.Relationship between orthostatic hypotension and white matterhyperintensity load in older patients with mild dementia. PLoS One 2012;7:e52196.","DOI":"10.1371\/journal.pone.0052196"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01923-X"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02439557"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01139.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.686543"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001681"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431285"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22786"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.08.020"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6627-y"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0016"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171038"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2015.08.013"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26632"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314123"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:57:49Z","timestamp":1694782669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/gps.4964"],"URL":"https:\/\/doi.org\/10.1002\/gps.4964","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"2018-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}