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Although modification of technical parameters related to ECT administration has led to some limited improvement in this regard, attention is now being increasingly focussed on pharmacological approaches. A number of agents have been explored in this context, however, as far as we are aware, the use of thiamine has not yet been investigated. We present three cases of elderly patients undergoing ECT for major depression in whom thiamine administration was associated with beneficial effects on post\u2010ECT confusion. We review the evidence suggesting that thiamine deficiency may be implicated in the confusional state following ECT and recommend that consideration be given to its use in preventing and treating this problematic side\u2010effect, especially in elderly patients. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/gps.498","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:25:48Z","timestamp":1033903548000},"page":"189-192","source":"Crossref","is-referenced-by-count":11,"title":["Using thiamine to reduce post\u2010ECT confusion"],"prefix":"10.1002","volume":"17","author":[{"given":"C.R.","family":"Linton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.J.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,25]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"The Practice of Electroconvulsive Therapy: Recommendations for Treatment, Training and Privileging","author":"American Psychiatric Association","year":"1990"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/07315724.1992.12098238","article-title":"Vitamin B1, B2 and B6. 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