{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:36:36Z","timestamp":1772458596863,"version":"3.50.1"},"reference-count":84,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH074567"],"award-info":[{"award-number":["R01 MH074567"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The ventrolateral prefrontal cortex (vlPFC) has been speculated to play an important role in complex processes that allow emotional factors to influence human cognition. Accumulating evidence from human neuroimaging studies, in conjunction with studies of patients with lesions and animal models, shed light on the role of the vlPFC in emotion regulation (ER). This review aims to discuss and integrate recent findings related to vlPFC's role in ER in the context of aging, drawing from diverse sources, and suggest future directions for research utilizing transcranial magnetic stimulation (TMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Design<\/jats:title><jats:p>We summarize findings from the existing literature investigating the neural basis of frontal\u2010lobe mediated ER and then highlight major findings from recent studies directly comparing healthy younger and older adult groups. We conclude by pointing to unaddressed questions worth pursuing in future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Discussion<\/jats:title><jats:p>We propose future research directions utilizing TMS to answer key unaddressed questions. Moreover, we discuss the potential advantages, challenges, and limitations of using TMS as a complement to the existing neuroimaging methods in ER.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.4982","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T09:53:53Z","timestamp":1538042033000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-1991","authenticated-orcid":false,"given":"Joseph U.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Utah  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5330-4038","authenticated-orcid":false,"given":"Sara L.","family":"Weisenbach","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Utah  Salt Lake City UT USA"},{"name":"VA Salt Lake  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-2923","authenticated-orcid":false,"given":"David H.","family":"Zald","sequence":"additional","affiliation":[{"name":"Department of Psychological Science Vanderbilt University  Nashville TN USA"},{"name":"Department of Psychiatry Vanderbilt University School of Medicine  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/1089-2680.2.3.271"},{"key":"e_1_2_10_3_1","first-page":"3","volume-title":"Handbook of Emotion Regulation","author":"Gross JJ","year":"2007"},{"key":"e_1_2_10_4_1","first-page":"367","volume-title":"Current Theory and Research in Motivation, Vol. 36. Nebraska Symposium on Motivation, 1988: Socioemotional development","author":"Thompson RA","year":"1990"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00175"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2013.05.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6924.2008.00085.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.11.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2007.10.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15374424jccp3304_10"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.21888"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_13_1","volume-title":"ICD\u201010: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision","author":"World Health Organization","year":"2004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.12.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06751.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.030"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.5.776"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.031"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00446-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.046"},{"key":"e_1_2_10_21_1","first-page":"681","volume-title":"Anxiety and The Anxiety Disorders","author":"Tellegen A","year":"1985"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.98.2.219"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1798"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3323"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00248-5"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.08.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3215-05.2006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsm029"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.001"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23053"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198565741.003.0012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht154"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.21.1.40"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0956-7976.2004.01503011.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.20.4.554"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00149-5"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721410388395"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.4.590"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbp132"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127488"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/1528-3542.7.4.705"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00339"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0039246"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/59.6.P261"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20903"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.23.1.209"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2008.02258.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.08.005"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.09.009"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3252-09.2009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.6.4.533"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700611062"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq030"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.06.004"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00296"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.9.061206.133100"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163604"},{"issue":"3","key":"e_1_2_10_59_1","first-page":"121","article-title":"Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage","volume":"17","author":"Meyers CA","year":"1992","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.437"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.85.4.594"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.08.012"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.03.007"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:SYNT.0000042951.25087.16"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/35018000"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892903770007344"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0804-06.2006"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129156"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01346-X"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.4.369"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.8.2.172"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01219-6"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291708003462"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002802"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.09.007"},{"issue":"2","key":"e_1_2_10_76_1","first-page":"101","article-title":"Increased positive emotional memory after repetitive transcranial magnetic stimulation over the orbitofrontal cortex","volume":"31","author":"Schutter DJ","year":"2006","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-008-0056-6"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-014-9268-3"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02522474"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.07.029"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024981"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-6-8"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01039-8"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00181"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691613504116"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.4982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.4982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.4982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:17:14Z","timestamp":1694510234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.4982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/gps.4982"],"URL":"https:\/\/doi.org\/10.1002\/gps.4982","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"2018-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}