{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:07:50Z","timestamp":1747148870424,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Approximately 10% to 30% of Alzheimer disease (AD) patients progress rapidly in severity and become more dependent on caregivers. Although several studies have investigated whether imaging biomarkers such as medial temporal atrophy (MTA) and posterior atrophy (PA) are useful for predicting the rapid progression of AD, their results have been inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to investigate the association of visually rated MTA and PA with rapid disease progression in AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of 159 AD patients who were initially diagnosed with mild AD and were followed for 1\u00a0year to determine whether they progressed rapidly (a decrease of three points or more on the Mini\u2010Mental State Examination over 1\u00a0year). We used 5\u2010point and 4\u2010point visual rating scales to assess MTA and PA, respectively. MTA and PA scores for each patient were dichotomized as normal (without atrophy) or abnormal (atrophy). We performed a logistic regression analysis to determine the odds ratios (ORs) of MTA and PA for rapid disease progression with adjustment for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the study population, 47 (29.6%) patients progressed rapidly. Visual assessment of the magnetic resonance imaging (MRI) scans revealed that 112 patients (70.4%) showed MTA, whereas 80 patients (50.3%) showed PA. The ORs with 95% confidence intervals for MTA and PA were 1.825 (0.819\u20104.070) and 2.844 (1.378\u20105.835), respectively. The association of visually assessed PA, but not MTA, with rapid progression was significant after adjustment for covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with mild AD, visual assessment of PA exhibits independent predictive value for rapid disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5072","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T07:55:02Z","timestamp":1549266902000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The usefulness of visual rating of posterior atrophy in predicting rapid cognitive decline in Alzheimer disease: A preliminary study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-6447","authenticated-orcid":false,"given":"Jeewon","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Neurology Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang\u2010Rai","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science and Engineering Korean Advanced Institute of Science and Technology  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Won","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology Kangwon National University Hospital  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jae","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Department of Neurology Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"163","article-title":"Predictive factors for rapid loss on the Mini\u2010Mental State Examination in Alzheimer's disease","volume":"9","author":"Dumont C","year":"2005","journal-title":"J Nutr Health Aging"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.10.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13314"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000094327.68399.59"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.8.1137"},{"issue":"10","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/BF03028618","article-title":"Rapid cognitive decline in Alzheimer's disease. 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