{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:42:15Z","timestamp":1771000935104,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association between benzodiazepines (BZDs) and Z\u2010drugs treatment and risk of burn injury in elders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a nested case\u2010control study. All subjects were aged 65 and older and enrolled in the National Health Insurance program in Taiwan, 2003 to 2012; 813 cases were identified with burn injury for the first time in their inpatient claims, and they were individually matched to 4879 controls based on age, gender, and index year. Benzodiazepines and Z\u2010drugs usage (doses, duration, half\u2010life) and the other covariates including comorbidities, health care utilization, and psychotropic medications used in the 365 days before index events were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increased risk of burn injury hospitalization in elders was observed among current Z\u2010drugs users compared with nonusers (adjusted odds ratio [AOR] = 1.59, 95% confidence interval [CI] [1.23, 2.07]). BZDs at high (AOR = 1.81, 95% CI [1.12, 2.94] and medium dosage (AOR = 1.53, 95% CI [1.15, 2.04] and Z\u2010drugs at medium dosage (AOR = 1.60, 95% CI [1.20, 2.12]) were all significantly increased the burn\u2010related injury requiring hospitalization. Polypharmacy of anxiolytic and hypnotic BZDs, long\u2010 and short\u2010acting BZDs, and more than one BZD with or without Z\u2010drugs also increased the risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BZDs and Z\u2010drugs prescriptions in elders may be associated with increased risk of burn injury hospitalization. When prescribing BZDs and Z\u2010drugs, clinicians should exercise caution with the elderly to minimize risks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5155","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T12:14:01Z","timestamp":1558440841000},"page":"1465-1472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hospitalized burn injury risk associated with benzodiazepines and Z\u2010drugs in elders: A population\u2010based case\u2010control study"],"prefix":"10.1002","volume":"34","author":[{"given":"Pei\u2010Jung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychiatry Chang Gung Memorial Hospital at Linkou and Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan\u2010Wen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chang Gung Memorial Hospital at Linkou and Chang Gung University  Taoyuan Taiwan"},{"name":"Division of Rehabilitation &amp; 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