{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:51:02Z","timestamp":1783533062799,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grants\u2010in\u2010Aid for Scientific Research (C) 15K09841"],"award-info":[{"award-number":["Grants\u2010in\u2010Aid for Scientific Research (C) 15K09841"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A direct causal relationship of cerebrovascular risk factors\/stroke to amyloid \u03b2 (A\u03b2) deposition has yet to be shown. We conducted [<jats:sup>11<\/jats:sup>C] Pittsburgh compound B (PiB)\u2013positron emission tomography (PET) analysis on subacute ischemic stroke patients and healthy controls. We hypothesized that subacute ischemic stroke patients would show focal A\u03b2 accumulation in cortical regions, which would increase and extend over time during the chronic phase after stroke onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were recruited 14 to 28\u00a0days after acute subcortical ischemic stroke and examined with [<jats:sup>11<\/jats:sup>C]PiB\u2010PET scans. Regional time\u2010activity data were analyzed with the Logan graphical method. Whole brain voxel\u2010based analysis was conducted to compare stroke patients with healthy controls. We also performed longitudinal comparison of patients with successive [<jats:sup>11<\/jats:sup>C]PiB\u2010PET scans 1\u00a0year after stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Voxel\u2010based analysis revealed a significant increase of [<jats:sup>11<\/jats:sup>C]PiB\u2010BP<jats:sub>ND<\/jats:sub> of the precuneus\/posterior cingulate cortex (PCu\/PCC) in stroke patients at the subacute stage. Based on stepwise multiple regression analysis of [<jats:sup>11<\/jats:sup>C]PiB\u2010BP changes during follow\u2010up as the dependent variable, years of education was the best independent correlate. There was a significant negative relationship between changes in [<jats:sup>11<\/jats:sup>C]PiB\u2010BP and years of education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that processes before and after the onset of ischemic stroke may trigger A\u03b2 deposition in the PCu\/PCC, whereby amyloid deposition begins at an early stage of Alzheimer's disease (AD). Our findings support the existence of a cooperative association between vascular risk factors\/stroke and AD progression. Further, educational achievement had a protective effect against the increase in A\u03b2 accumulation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5178","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T04:43:08Z","timestamp":1563770588000},"page":"1651-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Amyloid \u03b2 deposition in subcortical stroke patients and effects of educational achievement: A pilot study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-5795","authenticated-orcid":false,"given":"Fumihiko","family":"Yasuno","sequence":"first","affiliation":[{"name":"Department of Psychiatry National Center for Geriatrics and Gerontology  Japan"},{"name":"Department of Neurology National Cerebral and Cardiovascular Center  Suita 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