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Herein, we describe the sociodemographic characteristics of a large sample of resilient APOE<\/jats:italic> \u03b54+ women from the Women's Health Initiative Memory Study (WHIMS) and compare them to noncarriers and APOE<\/jats:italic> \u03b54+ women who developed CI before age 80.<\/jats:p><\/jats:sec>Methods<\/jats:title>Women were recruited for clinical trials evaluating postmenopausal hormone therapy and incidence of dementia. During posttrial follow\u2010up, cognitive status was adjudicated annually. Among 5716 women, we compared groups by APOE<\/jats:italic> \u03b54 status using logistic regression, covarying for treatment, demographics, lifestyle, cardiovascular and physical function, well\u2010being, and self\u2010rated general health.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 557 APOE<\/jats:italic> \u03b54+ women, those who survived to age 80+ without CI had higher baseline self\u2010rated general health (odds ratio [OR]: 1.02; 95% confidence interval [CI], 1.01\u20101.04) and cognitive scores (OR: 1.18; 95% CI, 1.12\u20101.25) than those who did not reach age 80 without CI. Baseline high total cholesterol and low\u2010density lipoprotein (LDL) levels were similar across APOE<\/jats:italic> \u03b54+ groups but were higher compared with APOE<\/jats:italic> \u03b54\u2212 women. Among women who survived to 80+ without CI, more APOE<\/jats:italic> \u03b54+ women had a history of high total cholesterol (P<\/jats:italic> = .003) and LDL cholesterol (OR: 1.01; 95% CI, 1.00\u20101.01). There were no differences in hypertension, diabetes, or other vascular risk factors in APOE<\/jats:italic> \u03b54+ women compared with noncarriers.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Results highlight the importance of baseline cognitive function and general health for late\u2010life cognition among \u03b54+ women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5199","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:28:36Z","timestamp":1565958516000},"page":"1833-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cognitive resilience among APOE<\/i> \u03b54 carriers in the oldest old"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-3513","authenticated-orcid":false,"given":"Kathleen M.","family":"Hayden","sequence":"first","affiliation":[{"name":"Department of Social Sciences and Health Policy, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-7888","authenticated-orcid":false,"given":"Sarah A.","family":"Gaussoin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie C.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie C.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"},{"name":"Department of Internal Medicine, Section on Geriatrics and Gerontology Wake Forest School of Medicine Winston\u2010Salem NC"},{"name":"Department of Neurology Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of California San Diego School of Medicine La Jolla CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary A.","family":"Tindle","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Centers (GRECC), Veterans Affairs Tennessee Valley Healthcare System Vanderbilt University Medical Center Nashville TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Mossavar\u2010Rahmani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine New York City NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khyobeni","family":"Mozhui","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Health Science Center Memphis TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly M.","family":"Snively","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Social Sciences and Health Policy, Division of Public Health Sciences Wake Forest School of Medicine Winston\u2010Salem NC"},{"name":"Department of Psychiatry and Behavioral Medicine Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Resnick","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral Neuroscience National Institute on Aging Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"801","article-title":"Resilience and reserve capacity in later adulthood: Potentials and limits of development across the life span","volume":"2","author":"Staudinger UM","year":"1995","journal-title":"Dev 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