{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:26:11Z","timestamp":1768886771851,"version":"3.49.0"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HC15C1509"],"award-info":[{"award-number":["HC15C1509"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102015R1C1A1A01052172"],"award-info":[{"award-number":["NRF\u20102015R1C1A1A01052172"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the presence of cerebral amyloidopathy and its associations with performances on neurocognitive tests and clinical features in depressed elders with mild cognitive impairment (MCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/design<\/jats:title><jats:p>In total, 94 older adults with concomitant MCI and some depressive symptoms were included in this study. Cerebral amyloidopathy was evaluated using <jats:sup>18<\/jats:sup>F\u2010florbetaben\u2010positron emission tomography. A standardized neurocognitive test battery and brain magnetic resonance imaging (MRI) were administered to all subjects. We examined the Apolipoprotein E genotype using a polymerase chain reaction\u2010based method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 94 initial participants, seven participants were excluded because of failure to undergo MRI or complete the neuropsychological battery. Among 87 subjects, 45 elders (51.7%) had cerebral amyloidopathy and were classified as the concomitant depression and MCI with cerebral amyloid\u2010accumulation\u2010positive (CDAP) group; others were classified as the concomitant depression and MCI with cerebral amyloid\u2010accumulation\u2010negative (CDAN) group. Poorer performances on word list recall and constructional recall were observed in the CDAP group than in the CDAN group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicate that around half of older adults with concomitant MCI and some depressive symptoms might be prone to have Alzheimer dementia. Results of neurocognitive tests possibly aid in discerning the presence of cerebral amyloidopathy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5209","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T05:49:21Z","timestamp":1567748961000},"page":"1907-1915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between brain amyloid accumulation and neuropsychological characteristics in elders with depression and mild cognitive impairment"],"prefix":"10.1002","volume":"34","author":[{"given":"HyunChul","family":"Youn","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Korea University Graduate School  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-8907","authenticated-orcid":false,"given":"Changsu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Korea University Ansan Hospital Korea University College of Medicine  Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0318-5069","authenticated-orcid":false,"given":"Hyun\u2010Ghang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"},{"name":"Korea University Research Institute of Mental Health  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.08.015"},{"issue":"16","key":"e_1_2_11_3_1","first-page":"2330","article-title":"Prevalence of depressive disorders among frail elderly, assessed by psychogeriatricians, general practitioners and geriatricians","volume":"162","author":"Djernes JK","year":"2000","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.174.4.307"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1961.tb07367.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12669"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.5.530"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111922"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.112.118307"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1481"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.60"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.03.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.07.014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43176-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"issue":"3","key":"e_1_2_11_18_1","first-page":"508","article-title":"A normative study of the Mini\u2010Mental State Examination in the Korean elderly","volume":"41","author":"Lee DY","year":"2002","journal-title":"J Korean Neuropsychiatr Assoc"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"e_1_2_11_20_1","volume-title":"Seoul Neuropsychological Screening Battery","author":"Kang Y","year":"2003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/57.1.P47"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617704101094"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1071"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"61","article-title":"A study of standardization of Korean form of Geriatric Depression Scale (KGDS)","volume":"1","author":"Jung IK","year":"1997","journal-title":"J Korean Geriatr Psychiatry"},{"issue":"2","key":"e_1_2_11_27_1","first-page":"189","article-title":"A study on the reliability and validity of Seoul\u2010Instrumental Activities of Daily Living(S\u2010IADL)","volume":"43","author":"Ku HM","year":"2004","journal-title":"J Korean Neuropsychiatr Assoc"},{"issue":"4","key":"e_1_2_11_28_1","first-page":"206","article-title":"A study on the reliability and validity of Seoul\u2010Activities of Daily Living(S\u2010ADL)","volume":"8","author":"Ku HM","year":"2004","journal-title":"J Korean Geriatr Soc"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2000.15.6.609"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.967"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2205-4"},{"key":"e_1_2_11_36_1","volume-title":"Summary of Product Characteristics","author":"Piramal Imaging Limited","year":"2014"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336-015-0102-6"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2975-4"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4215"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213000689"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282f16db4"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8721.2008.00567.x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-006-9002-x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.019"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200201000-00012"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700035662"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004643"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz025"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.01.006"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.02.020"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5891"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c918b5"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.08.017"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.06.029"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00190-4"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1996.0039"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1148"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.5209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:22:27Z","timestamp":1694240547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/gps.5209"],"URL":"https:\/\/doi.org\/10.1002\/gps.5209","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]},"assertion":[{"value":"2019-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}