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We aimed to clarify the neural substrates of sleep disturbances in patients with DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated sleep disturbances, neuropsychiatric symptoms, and brain glucose metabolism in 22 patients with probable DLB using actigraphy, the Neuropsychiatric Inventory (NPI), and <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (FDG) positron emission tomography, respectively. Total sleep time (TST) and average activity count per minute (AAC) during sleep were calculated for seven consecutive days via actigraphy. We investigated associations between FDG uptake and the actigraphy parameters using Statistical Parametric Mapping version 12b. Spearman's rank correlation coefficients were used to investigate associations among TST, AAC, and clinical symptoms. The level of statistical significance was set at <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05. <jats:italic>P<\/jats:italic> values were adjusted using the Benjamini\u2010Hochberg method for multiple comparisons. This study was registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (NCT00776347).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TST exhibited a significant positive association with FDG uptake in the bilateral orbitofrontal cortex and left thalamus, while AAC exhibited a significant negative association with FDG uptake in the left thalamus and the left parieto\u2010occipital region. FDG uptake in the left pulvinar was associated with both TST and AAC. In addition, TST exhibited a significant negative association with the NPI hallucinations score (<jats:italic>r<\/jats:italic> = \u22120.66, <jats:italic>P<\/jats:italic> = .001), while AAC exhibited significant positive associations with the NPI delusions (<jats:italic>r<\/jats:italic> = 0.70, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and hallucinations (<jats:italic>r<\/jats:italic> = 0.63, <jats:italic>P<\/jats:italic> = .002) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TST and bodily activity during sleep are associated with dysfunction of the left pulvinar and the severity of hallucinations in patients with DLB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5315","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T05:31:25Z","timestamp":1588138285000},"page":"934-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Thalamic pulvinar metabolism, sleep disturbances, and hallucinations in dementia with Lewy bodies: Positron emission tomography and actigraphy study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-1469","authenticated-orcid":false,"given":"Hideki","family":"Kanemoto","sequence":"first","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kazui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Neuropsychiatry, Kochi Medical School Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Psychiatry Osaka University Health and Counseling Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko T.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eku","family":"Shimosegawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging in Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25523"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e31827c6bdd"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.2.117"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.02.039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151000"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4470"},{"key":"e_1_2_9_11_1","first-page":"189","article-title":"Mini\u2010mental state","volume":"12","author":"Folstein M","year":"1975","journal-title":"A Practical Method for Grading the Cognitive State of Patients for the Clinician J Psychiatr Res"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199307040-00002"},{"key":"e_1_2_9_13_1","unstructured":"WechslerD.WMS\u2010R Manual. 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