{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:30:53Z","timestamp":1790767853099,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Altered awareness of cognitive and neuropsychiatric symptoms is a common feature of neurodegeneration, which can significantly impact on quality of life, medication concordance and personal safety. Elucidating how awareness is affected by common alpha\u2010synucleinopathies therefore has significant clinical relevance. We performed a systematic review of the literature on awareness of cognitive and neuropsychiatric symptoms in Parkinson's disease and Dementia with Lewy Bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Searches of PubMed and Web of Science were carried out, using keywords and MeSH subheadings, limited to papers in English dealing with humans. The terms \u201cParkinson's\u201d or \u201cLewy body\u201d were used to denote the disease of interest, combined with either \u201cagnosia\u201d, \u201canosognosia\u201d, \u201cinsight\u201d, \u201cmetacognition\u201d, or \u201cneuropsychology\u201d to denote the neuropsychological area of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>21 publications investigating awareness of cognitive symptoms, and 18 publications on awareness of neuropsychiatric symptoms were identified. The large majority focused on Parkinson's disease rather than Dementia with Lewy Bodies. Cognitively intact people with Parkinson's disease may over\u2010report cognitive symptoms, whilst those with cognitive impairment under\u2010report symptoms. Awareness of neuropsychiatric symptoms is likely to decline over time, particularly in those with progressive cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Altered awareness of cognitive and neuropsychiatric symptoms is common in Parkinson's disease. Symptom awareness varies significantly between individuals, and appears to be influenced by mood and global cognitive functioning, with executive functioning specifically implicated. There are gaps in our understanding of how dopaminergic medications influence symptom awareness, and a need for longitudinal studies of how awareness changes over time in Parkinson's disease and Dementia with Lewy Bodies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5415","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:52:15Z","timestamp":1598935935000},"page":"15-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Altered awareness of cognitive and neuropsychiatric symptoms in Parkinson's disease and Dementia with Lewy Bodies: A systematic review"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-9619","authenticated-orcid":false,"given":"Catherine","family":"Pennington","sequence":"first","affiliation":[{"name":"Edinburgh Dementia Prevention University of Edinburgh  Edinburgh UK"},{"name":"Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Duncan","sequence":"additional","affiliation":[{"name":"Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Edinburgh Dementia Prevention University of Edinburgh  Edinburgh UK"},{"name":"Centre for Clinical Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.387"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3799"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23823"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8800-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1016-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25873"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-013-0988-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.083113"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21382"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.200"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.07.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu221"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2360-17.2018"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"Altered awareness of motor symptoms in Parkinson's disease and Dementia with Lewy Bodies: a systematic review","volume":"9","author":"Pennington C","year":"2020","journal-title":"Int J Geriatr Psychiatry"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"451","article-title":"Cognition in Parkinson's disease","volume":"45","author":"Basic J","year":"2017","journal-title":"Int Rev Neurobiol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/174079"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0016631"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.04.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10479"},{"key":"e_1_2_10_25_1","first-page":"144","article-title":"Mildly demented Alzheimer's patients, but not mildly cognitively impaired Parkinson's disease patients, lack insight regarding their level of everyday executive functioning","volume":"11","author":"Zec R","year":"1999","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004523"},{"key":"e_1_2_10_27_1","unstructured":"GoetzCG OuyangB Negron Glenn StebbinsAT. 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