{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:21:13Z","timestamp":1791580873840,"version":"4.3.4"},"reference-count":131,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>When a genetic cause is suspected in a person with dementia, it creates unique diagnostic and management challenges to the treating clinician. Many clinicians may be unaware of the practicalities surrounding genetic testing for their patients, such as when to test and what tests to use and how to counsel patients and their families. This review was conducted to provide guidance to clinicians caring for patients with dementia regarding clinically relevant genetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed for studies that involved genetics of dementia up to March 2020. Patient file reviews were also conducted to create composite cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In addition to families where a strong Mendelian pattern of family history is seen, people with younger age of onset, especially before the age of 65 years were found to be at an increased risk of harbouring a genetic cause for their dementia. This review discusses some of the most common genetic syndromes, including Alzheimer disease, frontotemporal dementia, vascular dementia, Parkinson disease dementia\/dementia with Lewy bodies and some rarer types of genetic dementias, along with illustrative clinical case studies. This is followed by a brief review of the current genetic technologies and a discussion on the unique genetic counselling issues in dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inclusion of genetic testing in the diagnostic pathway in some patients with dementia could potentially reduce the time taken to diagnose the cause of their dementia. Although a definite advantage as an addition to the diagnostic repository, genetic testing has many pros and cons which need to be carefully considered first.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5535","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T22:26:01Z","timestamp":1615587961000},"page":"1158-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Genetic testing in dementia\u2010A medical genetics perspective"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-2932","authenticated-orcid":false,"given":"Aamira J.","family":"Huq","sequence":"first","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine Faculty of Medicine Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Sexton","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lacaze","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University The Alfred Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Neurosciences The Florey Institute The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsdon","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"Winship","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine The Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Medicine Faculty of Medicine Dentistry and Health Sciences University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230509"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180482"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a003491"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0224-0"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187068.92184.63"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bf997a"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190193"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.8.672"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-017-0518-4"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.10.1454"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.12.026"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002270"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S111821"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.08.016"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01664.x"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00828.x"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000086811.39675.79"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1192\/apt.bp.107.004572"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1206"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1502"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3182147f80"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.542308"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f5d4c4"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01072.x"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000334277.16896.fa"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180935"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023705"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0224-0"},{"key":"e_1_2_15_31_1","volume-title":"GeneReviews((R))","author":"Bird TD","year":"1993"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100480050033"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006262"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91209-9"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/325733a0"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800019200"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.012"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91112-1"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200008000-00003"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11283"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168979"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-219"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1821"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/689591"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-181108"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638622"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7638621"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq033"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.016"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400619"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2802"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0358-2"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694-180"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.4.569"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-10b"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-74"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.02.003"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.188"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.210"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw068"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802193380804"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31821d69b8"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002258"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30053-X"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.4950"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0707-9"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.6.925"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg204"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078928.20107.52"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.04.002"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr195"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105082"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1609"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f07e0c"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1332"},{"key":"e_1_2_15_83_1","first-page":"1403","article-title":"SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis","volume":"70","author":"Le Ber I","year":"2013","journal-title":"JAMA Neurol"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08971"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10353"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1436-x"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20086"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12213"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90057-X"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000265220.64396.b4"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.53"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70221-1"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.36"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70043-1"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318268452e"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70233-9"},{"issue":"2658","key":"e_1_2_15_99_1","first-page":"e1","article-title":"Defining the association of TMEM106B variants among frontotemporal lobar degeneration patients with GRN mutations and C9orf72 repeat expansions","volume":"35","author":"Lattante S","year":"2014","journal-title":"Neurobiol Aging"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70065-1"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.07.013"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1016-8"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21956"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000306632.43729.24"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1359315"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6855.673"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt367"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225ab77"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2019.28"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.09.007"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000139870.14385.3C"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1994.tb02645.x"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1105"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1359314"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-16"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002334"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.04.003"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0686-8"},{"key":"e_1_2_15_121_1","unstructured":"Choosing_Wisely.American College of medical genetics and Genomics: five things physicians and patients should question.2017."},{"key":"e_1_2_15_122_1","first-page":"353","article-title":"Avoiding versus seeking: the relationship of information seeking to avoidance, blunting, coping, dissonance, and related concepts","volume":"93","author":"Case DO","year":"2005","journal-title":"J Med Libr Assoc"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/1471301216684401"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213002639"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007244"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900907"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba4624"},{"key":"e_1_2_15_128_1","volume-title":"Gene Therapies to Slow or Stop the Neurodegenerative Process","author":"PrevailTherapeutics","year":"2020"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt534"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.017"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0609-7"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T16:56:11Z","timestamp":1693414571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,28]]},"references-count":131,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/gps.5535"],"URL":"https:\/\/doi.org\/10.1002\/gps.5535","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,28]]},"assertion":[{"value":"2020-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}