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We defined depression as having a score of \u22655 using the 15\u2010item Geriatric Depression Scale. We used regression splines to examine the pattern of depression risk with age and applied multivariable logistic regression to study factors associated with depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increasing age was associated with depression in an inverted J\u2010shape relationship with the highest odds ratio (OR) at age 75. Compared to the youngest\u2010old (&lt;70\u00a0years), the middle\u2010old (70\u201080\u00a0years) had higher odds of depression [OR\u00a0=\u00a01.20, 95% confidence interval (CI)\u00a0=\u00a01.09\u20131.31], while the oldest\u2010old (&gt;80\u00a0years) had no increased risk (OR\u00a0=\u00a01.01, 95% CI\u00a0=\u00a00.89\u20131.15). We also found demographic (men, lower education, unemployment), social (living alone, poor social support, no social activity) and health factors (instrumental limitations, poor physical function, function\u2010limiting pain, chronic diseases, cognitive impairment, poor sleep quality, poor self\u2010rated health) associated with depression. In stratified analysis by age groups, the OR estimates for lower education level, instrumental limitations and cognitive impairment decreased with age, whereas the risk of depression for men increased with age (all <jats:italic>p<\/jats:italic>\u2010values for interaction&lt;0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to the youngest\u2010old, the likelihood of depression was highest among middle\u2010old adults and decreased to null in the oldest\u2010old. The associations between some factors and depression were attenuated with age, suggesting a coping mechanism among oldest\u2010old survivors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5666","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T09:36:13Z","timestamp":1637746573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Factors associated with depression across age groups of older adults: The Singapore Chinese health study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-553X","authenticated-orcid":false,"given":"Jon","family":"Barrenetxea","sequence":"first","affiliation":[{"name":"Health Services and Systems Research Duke\u2010NUS Medical School Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, MOE Key Lab of Environment and Health School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Sociology\u00a0&amp; Centre for Family and Population Research National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon\u2010Puay","family":"Koh","sequence":"additional","affiliation":[{"name":"Healthy Longevity Translational Research Programme Yong Loo Lin School of Medicine, National University of Singapore  Singapore"},{"name":"Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR)  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