{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:11:15Z","timestamp":1790683875034,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Several European studies investigated the trends in psychotropic drug prescriptions (PDPs) among nursing home (NH) residents and reported a decline in antipsychotics prescriptions. Since the Dutch long\u2010term care system differs from other European systems (e.g. higher threshold for NH admission and trained elderly care physicians), this study explores the trends in PDPs in Dutch NH residents with dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study used data from nine studies, comprising two cross\u2010sectional studies, one cohort study, and six cluster\u2010randomized controlled trials, collected in Dutch NHs between 2003 and 2018. With multilevel logistic regression analysis, NHs as a random effect, we estimated the trends in PDPs overall and for five specific psychotropic drug groups (antipsychotics, antidepressants, anxiolytics, hypnotics, and anti\u2010dementia drugs), adjusting for confounders: age, gender, severity of dementia, severity of neuropsychiatric symptoms, and length of stay in NHs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The absolute prescription rate of antipsychotics was 37.5% in 2003 and decreased (OR\u00a0=\u00a00.947, 95% CI [0.926, 0.970]) every year. The absolute prescription rate of anti\u2010dementia drugs was 0.8% in 2003 and increased (OR\u00a0=\u00a01.162, 95% CI [1.105, 1.223]) per year. The absolute rate of overall PDPs declined from 62.7% in 2003 to 40.4% in 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among Dutch NH residents with dementia, the odds of antipsychotics prescriptions decreased by 5.3% per year while the odds of anti\u2010dementia drug prescriptions increased by 16.2%. There were no distinct trends in antidepressants, anxiolytics, and hypnotics prescriptions. However, overall PDPs were still high. The PDPs in NH residents remain an issue of concern.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5697","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T01:39:30Z","timestamp":1646444370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Time trends in psychotropic drug prescriptions in Dutch nursing home residents with dementia between 2003 and 2018"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-3120","authenticated-orcid":false,"given":"Jiamin","family":"Du","sequence":"first","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine University of Groningen University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Janus","sequence":"additional","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine University of Groningen University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Voorthuis","sequence":"additional","affiliation":[{"name":"Health Technology and Services Research Department Technical Medical Centre University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"van Manen","sequence":"additional","affiliation":[{"name":"Tactus Verslavingszorg  Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilco","family":"Achterberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Smalbrugge","sequence":"additional","affiliation":[{"name":"Department of Medicine for Older People Amsterdam Public Health Research Institute Amsterdam UMC \u2010 Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zwijsen","sequence":"additional","affiliation":[{"name":"Quality Department Korian Zorg, Korian Group  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Department of Primary and Community Care Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Department of Primary and Community Care Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Joachim en Anna Center for Specialized Geriatric Care  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sytse","family":"Zuidema","sequence":"additional","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine University of Groningen University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.09.027"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448806"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4911"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.07.002"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_13_7_1","volume-title":"Richtlijnen en praktijkvoering Probleemgedrag bij mensen met dementie\/Guidelines and Practice for Problem behavior in people with dementia","author":"Zuidema SU","year":"2018"},{"key":"e_1_2_13_8_1","volume-title":"CHMP Assessment Report on Conventional Antipsychotics Procedure under Article 5(3) of Regulation (EC) No 726\/2004","year":"2008"},{"key":"e_1_2_13_9_1","unstructured":"Arch Intern Med Impact of FDA black box advisory on antipsychotic medication use"},{"key":"e_1_2_13_10_1","volume-title":"The use of antipsychotic medication for people with dementia: time for action","author":"Banerjee S","year":"2009"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.09.003"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.08.014"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216001150"},{"key":"e_1_2_13_14_1","unstructured":"EMEA public statement on the safety of olanzapine (Zyprexa Zyprexa Velotab). 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