{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:37:30Z","timestamp":1787726250951,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Various informant\u2010based questionnaires are used in clinical practice to screen for pre\u2010stroke cognitive problems. However, there is no guidance on which tool should be preferred. We compared the validity of the two most commonly used informant\u2010based tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited consecutively admitted stroke patients. Patients' informants completed the Informant Questionnaire for Cognitive Decline in the Elderly Short Form (IQCODE\u2010SF, 16\u2010item) and Ascertain Dementia 8 (AD8). We assessed construct validity (accuracy) against a semi\u2010structured clinical interview for dementia or mild cognitive impairment (MCI), describing test accuracy metrics and comparing area under ROC curves (AUROC). We described criterion validity by evaluating associations between test scores and neuroimaging markers of dementia and overall \u2018brain frailty\u2019. Finally, we described prognostic validity comparing ROC curves for 18\u2010month clinical outcomes of dementia, death, stroke, and disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred\u2010thirty\u2010seven patient\u2010informant dyads were recruited. At usual\u00a0clinical cut\u2010points, the IQCODE\u2010SF had comparable sensitivity to the AD8 (both\u00a0=\u00a092%) for pre\u2010stroke dementia, but superior specificity (IQCODE\u2010SF: 82% vs. AD8: 58%). Youden index suggested that the optimal AD8 threshold for diagnosis of dementia is \u22654. The IQCODE\u2010SF demonstrated stronger associations with markers of generalised and medial\u2010temporal lobe atrophy, neurovascular disease, and overall brain frailty. IQCODE\u2010SF also demonstrated greater accuracy for predicting future dementia (IQCODE\u2010SF AUROC\u00a0=\u00a00.903, 95% CI\u00a0=\u00a00.798\u20131.00; AD8 AUROC\u00a0=\u00a00.821, 95% CI\u00a0=\u00a00.664\u20130.977).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both IQCODE\u2010SF and AD8 are valid measures of pre\u2010stroke dementia. Higher cut points for AD8 may improve performance in the acute stroke setting. Based on consistent superiority across a range of validity analyses, IQCODE\u2010SF may be preferable to AD8 for pre\u2010stroke dementia screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5700","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T06:55:49Z","timestamp":1646463349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparative validity of informant tools for assessing pre\u2010stroke cognitive impairment"],"prefix":"10.1002","volume":"37","author":[{"given":"Martin","family":"Taylor\u2010Rowan","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"McGuire","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow 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