{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:00Z","timestamp":1786977840380,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u00e2\u20ac\u2122s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Autonomic symptoms are a common feature of the synucleinopathies, and may be a distinguishing feature of prodromal Lewy body disease. We aimed to assess whether the cognitive prodrome of dementia with Lewy bodies, mild cognitive impairment (MCI) with Lewy bodies (MCI\u2010LB), would have more severe reported autonomic symptoms than cognitively healthy older adults, with MCI due to Alzheimer's disease (MCI\u2010AD) also included for comparison. We also aimed to assess the utility of an autonomic symptom scale in differentiating MCI\u2010LB from MCI\u2010AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010three individuals with MCI and 33 healthy controls were assessed with the Composite Autonomic Symptom Score 31\u2010item scale (COMPASS). Mild cognitive impairment patients also underwent detailed clinical assessment and differential classification of MCI\u2010AD or MCI\u2010LB according to current consensus criteria. Differences in overall COMPASS score and individual symptom sub\u2010scales were assessed, controlling for age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age\u2010adjusted severity of overall autonomic symptomatology was greater in MCI\u2010LB (Ratio\u00a0=\u00a02.01, 95% CI: 1.37\u20132.96), with higher orthostatic intolerance and urinary symptom severity than controls, and greater risk of gastrointestinal and secretomotor symptoms. MCI\u2010AD did not have significantly higher autonomic symptom severity than controls overall. A cut\u2010off of 4\/5 on the COMPASS was sensitive to MCI\u2010LB (92%) but not specific to this (42% specificity vs. MCI\u2010AD and 52% vs. healthy controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mild cognitive impairment with Lewy bodies had greater autonomic symptom severity than normal ageing and MCI\u2010AD, but such autonomic symptoms are not a specific finding. The COMPASS\u201031 may therefore have value as a sensitive screening test for early\u2010stage Lewy body disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.5703","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T05:07:57Z","timestamp":1647580077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of autonomic symptoms may assist with early\u00a0identification of mild cognitive impairment with Lewy\u00a0bodies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-3150","authenticated-orcid":false,"given":"Calum A.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Frith","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A. H.","family":"Barker","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Durcan","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lawley","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Barnett","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Firbank","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Roberts","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u2010Paul","family":"Taylor","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Allan","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Exeter University  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Yarnall","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00363"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094971"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz111"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0706-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-62493-4","volume-title":"The Relationship between the Most Common Subtypes of Dementia and Orthostatic Hypotension in Older Adults","author":"Isik AT","year":"2021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4742"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339363"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24877"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.05.004"},{"key":"e_1_2_8_13_1","article-title":"The accuracy of cardiac innervation scintigraphy for mild cognitive impairment with Lewy bodies","author":"Roberts G","journal-title":"Neurology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720002901"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Accuracy of dopaminergic imaging as a biomarker for mild cognitive impairment with Lewy bodies","author":"Roberts G","year":"2020","journal-title":"Br J Psychiatry"},{"key":"e_1_2_8_16_1","article-title":"Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling","author":"Firbank MJ","year":"2020","journal-title":"J Neurol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.10.013"},{"key":"e_1_2_8_18_1","article-title":"Uniformity of cardiac (123)I\u2010MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia","author":"Roberts G","year":"2019","journal-title":"J Nucl Cardiol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa238"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136399"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25923"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-019-0581-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005521"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03819.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls214"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly188"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft213"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219640.59984.a7"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5703","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:23:23Z","timestamp":1692969803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/gps.5703"],"URL":"https:\/\/doi.org\/10.1002\/gps.5703","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]},"assertion":[{"value":"2021-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"gps.5703"}}