{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:24:49Z","timestamp":1770722689706,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019219","name":"National Institute for Health Research Applied Research Collaboration South West Peninsula","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Orthostatic hypotension is a common feature of normal ageing, and age\u2010related neurodegenerative diseases, in particular the synucleinopathies including dementia with Lewy bodies. Orthostatic hypotension and other abnormal cardiovascular responses may be early markers of Lewy body disease. We aimed to assess whether abnormal blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre would be more common in mild cognitive impairment with Lewy bodies (MCI\u2010LB) than MCI due to Alzheimer's disease (MCI\u2010AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MCI patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a089) underwent longitudinal clinical assessment with differential classification of probable MCI\u2010LB, possible MCI\u2010LB, or MCI\u2010AD, with objective autonomic function testing at baseline. Blood pressure and heart rate responses to active stand and Valsalva manoeuvre were calculated from beat\u2010to\u2010beat cardiovascular data, with abnormalities defined by current criteria, and age\u2010adjusted group differences estimated with logistic models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Orthostatic hypotension and abnormal heart rate response to orthostatic challenge were not more common in probable MCI\u2010LB than MCI\u2010AD. Heart rate abnormalities were likewise not more common in response to Valsalva manoeuvre in probable MCI\u2010LB. An abnormal blood pressure response to Valsalva (delayed return to baseline\/absence of overshoot after release of strain) was more common in probable MCI\u2010LB than MCI\u2010AD. In secondary analyses, magnitude of blood pressure drop after active stand and 10\u2010s after release of Valsalva strain were weakly correlated with cardiac sympathetic denervation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Probable MCI\u2010LB may feature abnormal blood pressure response to Valsalva, but orthostatic hypotension is not a clear distinguishing feature from MCI\u2010AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5709","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T08:19:51Z","timestamp":1648887591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-3150","authenticated-orcid":false,"given":"Calum A.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Frith","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally A. H.","family":"Barker","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory","family":"Durcan","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Lawley","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Barnett","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Firbank","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Roberts","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Paul","family":"Taylor","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Biomedical Research Building, Campus for Ageing and Vitality Newcastle University  Newcastle upon Tyne 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