{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:06:58Z","timestamp":1788278818808,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Late\u2010onset bipolar disorder (LOBD) represents a significant subgroup of bipolar disorder (BD). However, knowledge for this group is mostly extrapolated from small studies in subjects with early\/mixed age of illness onset. In this global sample of older adults with BD (OABD: \u226550\u00a0years old) we aim to characterize the sociodemographic and clinical presentation of LOBD (\u226540\u00a0years at BD onset) compared to early\u2010onset BD (EOBD: &lt;40\u00a0years at BD onset).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Global Aging and Geriatric Experiments in Bipolar Disorder consortium provided international data on 437 older age bipolar disorder participants. We compared LOBD versus EOBD on depression, mania, functionality, and physical comorbidities. Exploratory analyses were performed on participants with BD onset \u226550\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LOBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0105) did not differ from EOBD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0332) on depression, mania, global functioning, nor employment status (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Late\u2010onset bipolar disorder was associated with higher endocrine comorbidities (odds ratio\u00a0=\u00a01.48, [95%CI\u00a0=\u00a01.0,12.1], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). This difference did not remain significant when subjects with BD onset \u226550\u00a0years old were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This study is limited by the retrospective nature of the variable age of onset and the differences in evaluation methods across studies (partially overcame by harmonization processes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present analysis is in favor of the hypothesis that LOBD might represent a similar clinical phenotype as classic EOBD with respect to core BD symptomatology, functionality, and comorbid physical conditions. Large\u2010scale global collaboration to improve our understanding of BD across the lifespan is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5833","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T04:27:51Z","timestamp":1666672071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical correlates of late\u2010onset versus early\u2010onset bipolar disorder in a global sample of older adults"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-9261","authenticated-orcid":false,"given":"Paola","family":"Lavin","sequence":"first","affiliation":[{"name":"GeriPARTy Research Group Jewish General Hospital  Montreal Quebec Canada"},{"name":"Lady Davis Research Institute McGill University  Montreal Quebec Canada"},{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Buck","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-6199","authenticated-orcid":false,"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Lin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics, and Occupational Health McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa T.","family":"Eyler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego  San Diego California USA"},{"name":"Desert\u2010Pacific Mental Illness Research Education and Clinical Center San Diego Healthcare System  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-0318","authenticated-orcid":false,"given":"Annemieke","family":"Dols","sequence":"additional","affiliation":[{"name":"GGZ InGeest Amsterdam UMC VU Medical Center Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary P.","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent P.","family":"Forester","sequence":"additional","affiliation":[{"name":"McLean Hospital  Belmont Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestes V.","family":"Forlenza","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience Instituto de Psiquiatr\u00eda Hospital da Universidad de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-988X","authenticated-orcid":false,"given":"Ariel","family":"Gildengers","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Addiction &amp; Mental Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang\u2010Ying","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Hospital Clinic University of Barcelona IDIBAPS CIBERSAM  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-5405","authenticated-orcid":false,"given":"Sigfried","family":"Schouws","sequence":"additional","affiliation":[{"name":"GGZ InGeest Amsterdam UMC VU Medical Center Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farren B. 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