{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:55Z","timestamp":1790372395892,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Off\u2010label prescriptions of antidepressants may be of special concern in older\u2010adults. We aimed to study the potential off\u2010label use of antidepressants among adults \u226565\u00a0years by describing the patterns, trends, and factors associated with missing and unspecified treatment indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used registry data to describe indications of all antidepressant prescriptions (<jats:italic>N<\/jats:italic>\u00a0=\u00a013.8 million) redeemed by older\u2010adults in 2006\u20132019. We investigated factors associated with off\u2010label use by considering prescriptions with missing and unspecified indications of the first antidepressant prescription using a multinomial logistic regression with the \u2018depression\u2019 indication as a reference category and reported odds ratios (ORs) with 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 18.1% of all antidepressant prescriptions had missing indications, and 9.9% had unspecified indications. The proportion of potential off\u2010label use based on missing and unspecified prescriptions remained mostly consistent during 2006\u20132019. We identified similar associations in user characteristics whether considering missing or unspecified first prescription. ORs with 95% CI were raised in non\u2010western ethnicity (vs. Danish, 1.12 (0.99\u20131.26) for missing indication and 1.28 (1.11\u20131.48) for unspecified indication) and female sex (vs. male, 1.05 (1.02\u20131.07) and 1.05 (1.02\u20131.07) respectively). ORs were reduced for shorter educational attainment (vs. long, 0.90 (0.87\u20130.94) and 0.92 (0.88\u20130.96)), older age (\u226581 vs. 67\u201370\u00a0years, 0.66 (0.65\u20130.71) and 0.73 (0.70\u20130.76)) and hospital psychiatric diagnosis (per diagnosis 0.76 (0.73\u20130.78) and 0.88 (0.86\u20130.91)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nearly one\u2010third of all antidepressant prescriptions redeemed by older\u2010adults in Denmark had either missing or unspecified treatment indications. Whether these prescriptions were actual off\u2010label use needs to be validated. Clinicians should pay special attention to patients' characteristics linking missing and unspecified indications and maintain adequate documentation while prescribing medication.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5841","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:28:41Z","timestamp":1667885321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment indications and potential off\u2010label use of antidepressants among older adults: A population\u2010based descriptive study in Denmark"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3651-4612","authenticated-orcid":false,"given":"Kazi","family":"Ishtiak\u2010Ahmed","sequence":"first","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus 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