{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:11:14Z","timestamp":1790683874115,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A frequent late Alzheimer's Disease and Related Diseases (ADRD) identification is described and may induce erratic health resource use. We aimed to describe healthcare use patterns preceding ADRD identification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied persons aged 65 or older, identified with incident ADRD in 2012 in the French health insurance database. Healthcare use covering a wide range of care in ambulatory and hospital settings during the period ranging from 18 to six months before ADRD identification was studied. The main dimensions of healthcare use patterns before ADRD identification were investigated in three age groups (65\u201374, 75\u201384, \u226585) through a multiple correspondence analysis. These dimensions were secondarily interpreted according to the 5\u2010year healthcare trajectory following ADRD identification, qualified as favorable (or not) by experts in the field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This research studied 36,990 subjects. Four dimensions raised in each age group. Two dimensions' interpretations were retrieved in all age groups: intensity of healthcare use, functional dependency. However, their rank differed along with the qualification of the future healthcare trajectory. Some specificities appeared in some age group. In the 65\u201374 and 75\u201384\u00a0years groups, there were dimensions reflecting healthcare use related to psychiatric or psycho\u2010behavioral disorders. In the \u226585 group, two dimensions reflected dependency related to other comorbidities, and organised medical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several dimensions emerged in line with erratic trajectories before ADRD identification. They underlined the need for actions towards ADRD identification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5849","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T04:30:40Z","timestamp":1669091440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Healthcare use patterns before Alzheimer's disease and related diseases identification and future healthcare trajectory"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-374X","authenticated-orcid":false,"given":"Ana\u00efs","family":"Couret","sequence":"first","affiliation":[{"name":"Agence R\u00e9gionale de Sant\u00e9 Occitanie  Toulouse France"},{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse Inserm Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Centre Hospitalier Universitaire de Toulouse  Toulouse France"},{"name":"Centre D'Investigation Clinique 1436 Team PEPSS \"Pharmacologie En Population CohorteS et BiobanqueS\" Centre Hospitalier Universitaire de Toulouse Inserm Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e9nie","family":"Gombault\u2010Datzenko","sequence":"additional","affiliation":[{"name":"Department of Medical Information (DIM) Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Renoux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-1808","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Villars","sequence":"additional","affiliation":[{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse Inserm Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"Geriatric Department Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gardette","sequence":"additional","affiliation":[{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse Inserm Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"Department of Epidemiology and Public Health Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Alzheimer\u2019s Disease International. World Alzheimer Report.The Global Impact of Dementia [Internet];2015. [cited 2020 Jun 12].https:\/\/www.alz.co.uk\/research\/WorldAlzheimerReport2015.pdf"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)32205\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(16)00062\u20104"},{"key":"e_1_2_10_5_1","unstructured":"Autorit\u00e9 de Sant\u00e9H.Maladie d\u2019Alzheimer et maladies apparent\u00e9es: diagnostic et prise en charge;2011. [Internet]https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2012\u201001\/reco2clics_maladie_d_alzheimer_et_maladies_apparentees_diagnostic_et_prise_en_charge_2012\u201001\u201016_14\u201017\u201037_906.pdf"},{"key":"e_1_2_10_6_1","unstructured":"Autorit\u00e9 de Sant\u00e9H.Guide parcours de soins des patients pr\u00e9sentant un trouble neurocognitif associ\u00e9 \u00e0 la maladie d\u2019Alzheimer ou \u00e0 une maladie apparent\u00e9e;2018. [Internet]https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2018\u201005\/parcours_de_soins_alzheimer.pdf"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(15)01124\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010019\u201001212\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0b013e3181a6bebc"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010170078"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258\u2010013\u20100038\u20109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.59.4.573"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.12.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.4945"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa236"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010018\u20100920\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14227"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv124"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102318\u201014\u201076"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.01.085"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010017\u20102620\u20106"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210416094639"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.08.008"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010017\u20100621\u20102"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010015\u20101860\u20109"},{"key":"e_1_2_10_26_1","unstructured":"AHRQ\u2014Quality Indicators [Internet]. [cited 2021 May 26].https:\/\/www.qualityindicators.ahrq.gov\/Modules\/PQI_TechSpec_ICD10_v2020.aspx"},{"key":"e_1_2_10_27_1","unstructured":"Indicateurs de coordination | Stats ATIH [Internet]. [cited 2021 May 26].https:\/\/www.scansante.fr\/applications\/indicateurs\u2010de\u2010coordination"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u20109\u201033"},{"key":"e_1_2_10_29_1","unstructured":"Caisse Nationale d\u2019Assurance Maladie.M\u00e9thodologie m\u00e9dicale de la cartographie des pathologies et des d\u00e9penses version G6 (ann\u00e9es 2012 \u00e0 2018) [Internet]. 2020 Feb [cited 2020 Jun 12].https:\/\/www.ameli.fr\/fileadmin\/user_upload\/documents\/Methodologie_medicale_cartographie.pdf"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0000000000000277"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12093"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999\u2010020\u201000331\u20100"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.04.012"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx068"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/1518\u20108345.2968.3166"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010015\u20101152\u20101"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15077"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000001774"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2410"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5849","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:42:30Z","timestamp":1692636150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/gps.5849"],"URL":"https:\/\/doi.org\/10.1002\/gps.5849","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2022-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5849"}}