{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T03:14:43Z","timestamp":1785640483065,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","award":["518"],"award-info":[{"award-number":["518"]}],"id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Depression in individuals with Alzheimer's disease (AD) is common, difficult to treat and inadequately understood. Previous studies have identified possible differences in regional brain atrophy in individuals with AD and depression, but the results have been inconsistent and some studies had less robust definitions of depression. We aimed to examine regional brain atrophy in two large dementia focused cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from Alzheimer's disease neuroimaging initiative (ADNI) and the National Alzheimer's Co\u2010ordinating Center (NACC), for those with data from at least one MRI scan. Depression ratings were available using the Geriatric Depression Scale (GDS) and Neuropsychiatric Inventory (NPI). Intermittent depressive symptoms were defined as one episode above threshold (\u22658 on GDS, \u22656 on NPI depression subscale and \u22652 on the Neuropsychiatric Inventory version Q depression sub\u2010scale) and persistent as \u22652 episodes. Derived regional volumetric data was available from ADNI and the NACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data was available from 698 individuals with AD in NACC and from 666 individuals in ADNI. We found no evidence of between group differences in regional brain volume at baseline, or of differential atrophy in NACC. In ADNI we found evidence of increased brain atrophy in several frontal brain areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Because this study was limited to those with MRI data, the numbers in some analyses were low. MRI parcellation differed between studies making direct comparison difficult. For some individuals only the NPI was used to rate depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have found mixed evidence of increased regional atrophy in depression in AD, mainly in frontal brain regions. We found no evidence to support a vascular basis for depression in AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5858","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T07:35:27Z","timestamp":1669966527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-4118","authenticated-orcid":false,"given":"Lindsey Isla","family":"Sinclair","sequence":"first","affiliation":[{"name":"Dementia Research Group Bristol Medical School University of Bristol  Bristol UK"},{"name":"Population Health Sciences Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive G.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Medical School University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.17r11772"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610216000508"},{"issue":"8","key":"e_1_2_10_4_1","article-title":"Antidepressants for treating depression in dementia","volume":"8","author":"Dudas R","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.5.857"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442\u2010200203000\u201000003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2015.12.4.516"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455127"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.1.68"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/jgp.0b013e31816029ec"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"218","article-title":"Frontal lobe hypoperfusion and depressive symptoms in Alzheimer disease","volume":"33","author":"Levy\u2010Cooperman N","year":"2008","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010015\u20100691\u20107"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246\u2010019\u201000758\u20101"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010017\u20108603\u2010z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010017\u20101854\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.161"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12352"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714541873"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140150"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.05.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282x20150068"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102013\u2010307110"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.043"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.02.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20103956(82)90033\u20104"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0b013e3181cb3e25"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.031"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.44.12.2308"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201029295\u20109"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02498-6_20"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4407"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14713"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2008.01175.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2019.195"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4933"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317508329480"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00642"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110738"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.049619"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067972"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264629"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.736"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017228"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1316"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2829"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.006"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4435"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12765"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gps.5858","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.5858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:43:10Z","timestamp":1692636190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.5858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/gps.5858"],"URL":"https:\/\/doi.org\/10.1002\/gps.5858","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]},"assertion":[{"value":"2022-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5858"}}