{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:24:54Z","timestamp":1790846694047,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL\u2010076200"],"award-info":[{"award-number":["R01HL\u2010076200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The adverse cardiovascular effects of benzodiazepines and Z\u2010drugs (jointly referred as BZDRs) have been of concern. Yet, little is known about the use of BZDRs in relation to mortality risk among older adults with myocardial infarction history (post\u2010MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a secondary analysis of the Alpha Omega Cohort study, comprising post\u2010MI patients aged 40\u201360\u00a0years. Self\u2010reported information on the use of BZDRs, including types and dose, was collected at baseline. Four categories of mortality were examined, namely all\u2010cause mortality, cardiovascular (CVD) mortality, cancer mortality, and non\u2010CVD\/non\u2010cancer mortality. Associations between BZDRs use, by types and doses, and mortality were estimated with Cox regression models, adjusted for demographic and classic cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 433 (8.9%) out of 4837 (21.8% females) patients reported BZDRs use at baseline. During a median follow\u2010up of 12.4\u00a0years, 2287 deaths were documented, of which 825 (36.1%) were due to CVD. BZDRs use was related to a statistically significantly higher risk of all\u2010cause and CVD mortality; adjusted hazard ratios [95% CI] were (1.31 [1.41, 1.52]) and (1.43 [1.14, 1.81]), respectively. These relationships were dose\u2010dependent\u2014patients using BZDRs on an as\u2010needed basis had similar risks compared to the non\u2010uses, whereas patients with a daily use schedule and increasing doses had higher risks (<jats:italic>p<\/jats:italic>\u2010value for trend: &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BZDRs use was independently associated with a higher risk of all\u2010cause and cardiovascular mortality in older post\u2010MI patients, and there was evidence for a dose\u2010dependent relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>NCT00127452 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ClinicalTrials.gov\">www.ClinicalTrials.gov<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.5861","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T16:25:43Z","timestamp":1670516743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Use of benzodiazepine and Z\u2010drugs and mortality in older adults after myocardial infarction"],"prefix":"10.1002","volume":"38","author":[{"given":"Shengxin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita S.","family":"Soedamah\u2010Muthu","sequence":"additional","affiliation":[{"name":"Center of Research on Psychological Disorders and Somatic Diseases (CoRPS) Department of Medical and Clinical Psychology Tilburg University  Tilburg The 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